Entry
Name
HSV VP16 to Oct-1-mediated transcription
Definition
(VP16+HCF+POU2F1) => (ICP0,ICP4,ICP22,ICP27,ICP47)
Expanded
(K19444+(3054,29915)+5451) => (K19436,K19445,K19441,K19443,K19446)
Class
nt06168 Herpes simplex virus 1 (HSV-1)
Type
Pathogen
Pathway
hsa05168 Herpes simplex virus 1 infection
Disease
H00365 Herpes simplex virus infection
Gene
3054 HCFC1; host cell factor C1
29915 HCFC2; host cell factor C2
5451 POU2F1; POU class 2 homeobox 1
Perturbant
K19444 (VP16) UL48; Simplexvirus tegument protein VP16
K19436 (ICP27) ICP0; Simplexvirus E3 ubiquitin-protein ligase ICP0
K19445 (ICP47) ICP4; Simplexvirus major viral transcription factor ICP4
K19441 () US1; Simplexvirus transcriptional regulator ICP22
K19443 () UL54; Simplexvirus mRNA export factor
K19446 () US12; HSV1 ICP47 protein
Reference
Authors
Wysocka J, Herr W
Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
Journal
Reference
Authors
LaBoissiere S, O'Hare P
Title
Analysis of HCF, the cellular cofactor of VP16, in herpes simplex virus-infected cells.
Journal
Reference
Authors
Pesola JM, Zhu J, Knipe DM, Coen DM
Title
Herpes simplex virus 1 immediate-early and early gene expression during reactivation from latency under conditions that prevent infectious virus production.
Journal
LinkDB
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