NETWORK: N00730
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Entry
N00730 Network
Name
IAV NS1 to RIG-I-like receptor signaling pathway
Definition
NS1 -| NFKB
Expanded
K19396 -| (4790+5970)
Class
nt06519
RLR signaling
nt06170
Influenza A virus (IAV)
Type
Pathogen
Pathway
hsa05164
Influenza A
Disease
H00398
Influenza
Gene
4790
NFKB1; nuclear factor kappa B subunit 1
5970
RELA; RELA proto-oncogene, NF-kB subunit
Perturbant
K19396
(NS1)
NS1; Influenza A virus non-structural protein 1
Reference
PMID:
23170167
Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
Title
Evasion of influenza A viruses from innate and adaptive immune responses.
Journal
Viruses 4:1438-76 (2012)
DOI:
10.3390/v4091438
Reference
PMID:
11090154
Authors
Wang X, Li M, Zheng H, Muster T, Palese P, Beg AA, Garcia-Sastre A
Title
Influenza A virus NS1 protein prevents activation of NF-kappaB and induction of alpha/beta interferon.
Journal
J Virol 74:11566-73 (2000)
DOI:
10.1128/JVI.74.24.11566-11573.2000
Reference
PMID:
22787206
Authors
Ruckle A, Haasbach E, Julkunen I, Planz O, Ehrhardt C, Ludwig S
Title
The NS1 protein of influenza A virus blocks RIG-I-mediated activation of the noncanonical NF-kappaB pathway and p52/RelB-dependent gene expression in lung epithelial cells.
Journal
J Virol 86:10211-7 (2012)
DOI:
10.1128/JVI.00323-12
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