KEGG   NETWORK: N00879
Entry
N00879                      Network                                
Name
PROK-PRKR-Gi-ERK signaling pathway
Definition
PROK1/2 -> PROKR1/2 -> GNAI -> ERK
  Expanded
(84432,60675) -> (10887,128674) -> (2770,2771,2773) -> (5594,5595)
Class
nt06325 Hormone/cytokine signaling
Type
Reference
Gene
84432  PROK1; prokineticin 1
60675  PROK2; prokineticin 2
10887  PROKR1; prokineticin receptor 1
128674  PROKR2; prokineticin receptor 2
2770  GNAI1; G protein subunit alpha i1
2771  GNAI2; G protein subunit alpha i2
2773  GNAI3; G protein subunit alpha i3
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Reference
PMID:18440852
  Authors
Ngan ES, Tam PK
  Title
Prokineticin-signaling pathway.
  Journal
Int J Biochem Cell Biol 40:1679-84 (2008)
DOI:10.1016/j.biocel.2008.03.010
Reference
PMID:11886876
  Authors
Lin DC, Bullock CM, Ehlert FJ, Chen JL, Tian H, Zhou QY
  Title
Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor.
  Journal
J Biol Chem 277:19276-80 (2002)
DOI:10.1074/jbc.M202139200
Reference
PMID:17200460
  Authors
Zhou QY
  Title
The prokineticins: a novel pair of regulatory peptides.
  Journal
Mol Interv 6:330-8 (2006)
DOI:10.1124/mi.6.6.6
Reference
PMID:15772293
  Authors
Chen J, Kuei C, Sutton S, Wilson S, Yu J, Kamme F, Mazur C, Lovenberg T, Liu C
  Title
Identification and pharmacological characterization of prokineticin 2 beta as a selective ligand for prokineticin receptor 1.
  Journal
Mol Pharmacol 67:2070-6 (2005)
DOI:10.1124/mol.105.011619
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