KEGG   NETWORK: N00918
Entry
N00918                      Network                                
Name
TRH-TRHR-PLCB-PKC signaling pathway
Definition
TRH -> TRHR -> GNAQ/11 -> PLCB -> (Ca2+,DAG) -> PKC -> TSHB
  Expanded
7200 -> 7201 -> (2776,2767) -> (23236,5330,5331,5332) -> (C00076,C00165) -> (5578,5579,5582) -> 7252
Class
nt06322 TRH-TSH-TH signaling
Type
Reference
Gene
7200  TRH; thyrotropin releasing hormone
7201  TRHR; thyrotropin releasing hormone receptor
2776  GNAQ; G protein subunit alpha q
2767  GNA11; G protein subunit alpha 11
23236  PLCB1; phospholipase C beta 1
5330  PLCB2; phospholipase C beta 2
5331  PLCB3; phospholipase C beta 3
5332  PLCB4; phospholipase C beta 4
5578  PRKCA; protein kinase C alpha
5579  PRKCB; protein kinase C beta
5582  PRKCG; protein kinase C gamma
7252  TSHB; thyroid stimulating hormone subunit beta
Metabolite
C00076  Calcium cation
C00165  Diacylglycerol
Reference
  Authors
Nakajima Y, Yamada M, Taguchi R, Shibusawa N, Ozawa A, Tomaru T, Hashimoto K, Saito T, Tsuchiya T, Okada S, Satoh T, Mori M
  Title
NR4A1 (Nur77) mediates thyrotropin-releasing hormone-induced stimulation of transcription of the thyrotropin beta gene: analysis of TRH knockout mice.
  Journal
PLoS One 7:e40437 (2012)
DOI:10.1371/journal.pone.0040437
Reference
  Authors
Garcia M, Barrio R, Garcia-Lavandeira M, Garcia-Rendueles AR, Escudero A, Diaz-Rodriguez E, Gorbenko Del Blanco D, Fernandez A, de Rijke YB, Vallespin E, Nevado J, Lapunzina P, Matre V, Hinkle PM, Hokken-Koelega AC, de Miguel MP, Cameselle-Teijeiro JM, Nistal M, Alvarez CV, Moreno JC
  Title
The syndrome of central hypothyroidism and macroorchidism: IGSF1 controls TRHR and FSHB expression by differential modulation of pituitary TGFbeta and Activin pathways.
  Journal
Sci Rep 7:42937 (2017)
DOI:10.1038/srep42937
LinkDB

DBGET integrated database retrieval system