KEGG   NETWORK: N00938
Entry
N00938                      Network                                
Name
Escherichia NleH to intrinsic apoptotic pathway
Definition
NleH -> TMBIM6 -| BAX
  Expanded
K16042 -> 7009 -| 581
Class
nt06524 Apoptosis
Type
Pathogen
Pathway
hsa05130  Pathogenic Escherichia coli infection
Disease
H00277  Enterohemorrhagic Escherichia coli (EHEC) infection
H00278  Enteropathogenic Escherichia coli (EPEC) infection
Gene
7009  TMBIM6; transmembrane BAX inhibitor motif containing 6
581  BAX; BCL2 associated X, apoptosis regulator
Perturbant
K16042 (NleH)  nleH; non-LEE-encoded effector NleH
Reference
  Authors
Hemrajani C, Berger CN, Robinson KS, Marches O, Mousnier A, Frankel G
  Title
NleH effectors interact with Bax inhibitor-1 to block apoptosis during enteropathogenic Escherichia coli infection.
  Journal
Proc Natl Acad Sci U S A 107:3129-34 (2010)
DOI:10.1073/pnas.0911609106
Reference
  Authors
Ashida H, Mimuro H, Ogawa M, Kobayashi T, Sanada T, Kim M, Sasakawa C
  Title
Cell death and infection: a double-edged sword for host and pathogen survival.
  Journal
J Cell Biol 195:931-42 (2011)
DOI:10.1083/jcb.201108081
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