KEGG   NETWORK: N01046
Entry
N01046                      Network                                
Name
Maneb to electron transfer in Complex III
Definition
Maneb -| CxIII -> CytC
  Expanded
C15231 -| (7386+4519+1537+7384+7385+(440567,7388)+7381+27089+29796+10975) -> C00524
Class
nt06463 Parkinson disease
nt06466 Pathways of neurodegeneration
Type
Env factor
Pathway
hsa05012  Parkinson disease
Disease
H00057  Parkinson disease
Gene
7386  UQCRFS1; ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
4519  CYTB; cytochrome b
1537  CYC1; cytochrome c1
7384  UQCRC1; ubiquinol-cytochrome c reductase core protein 1
7385  UQCRC2; ubiquinol-cytochrome c reductase core protein 2
440567  UQCRHL; ubiquinol-cytochrome c reductase hinge protein like
7388  UQCRH; ubiquinol-cytochrome c reductase hinge protein
7381  UQCRB; ubiquinol-cytochrome c reductase binding protein
27089  UQCRQ; ubiquinol-cytochrome c reductase complex III subunit VII
29796  UQCR10; ubiquinol-cytochrome c reductase, complex III subunit X
10975  UQCR11; ubiquinol-cytochrome c reductase, complex III subunit XI
Perturbant
C15231 (Maneb)  Maneb
Metabolite
C00524  Cytochrome c
Reference
  Authors
Mack JM, Schamne MG, Sampaio TB, Pertile RA, Fernandes PA, Markus RP, Prediger RD
  Title
Melatoninergic System in Parkinson's Disease: From Neuroprotection to the Management of Motor and Nonmotor Symptoms.
  Journal
Oxid Med Cell Longev 2016:3472032 (2016)
DOI:10.1155/2016/3472032
Reference
  Authors
Zhang J, Fitsanakis VA, Gu G, Jing D, Ao M, Amarnath V, Montine TJ
  Title
Manganese ethylene-bis-dithiocarbamate and selective dopaminergic neurodegeneration in rat: a link through mitochondrial dysfunction.
  Journal
J Neurochem 84:336-46 (2003)
DOI:10.1046/j.1471-4159.2003.01525.x
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