KEGG   NETWORK: N01052
Entry
N01052                      Network                                
Name
PINK1-Parkin-mediated MFN2 degradation
Definition
PINK1 -> PRKN -| MFN1/2
  Expanded
65018 -> 5071 -| (55669,9927)
Class
nt06463 Parkinson disease
nt06466 Pathways of neurodegeneration
Type
Reference
Pathway
hsa04137  Mitophagy - animal
Gene
65018  PINK1; PTEN induced kinase 1
5071  PRKN; parkin RBR E3 ubiquitin protein ligase
55669  MFN1; mitofusin 1
9927  MFN2; mitofusin 2
Reference
PMID:30154567
  Authors
Palikaras K, Lionaki E, Tavernarakis N
  Title
Mechanisms of mitophagy in cellular homeostasis, physiology and pathology.
  Journal
Nat Cell Biol 20:1013-1022 (2018)
DOI:10.1038/s41556-018-0176-2
Reference
PMID:29370689
  Authors
Yoo SM, Jung YK
  Title
A Molecular Approach to Mitophagy and Mitochondrial Dynamics.
  Journal
Mol Cells 41:18-26 (2018)
DOI:10.14348/molcells.2018.2277
Reference
PMID:29676259
  Authors
McLelland GL, Goiran T, Yi W, Dorval G, Chen CX, Lauinger ND, Krahn AI, Valimehr S, Rakovic A, Rouiller I, Durcan TM, Trempe JF, Fon EA
  Title
Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.
  Journal
Elife 7:e32866 (2018)
DOI:10.7554/eLife.32866
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