Entry |
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Name |
EGF-EGFR-Actin signaling pathway
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Definition |
EGF -> EGFR -> SRC -> CTTN -> NCK -> (WASL+WIPF) -> ARP2/3 -> (ACTB,ACTG1) |
Expanded |
1950 -> 1956 -> 6714 -> 2017 -> (4690,8440) -> (8976+(7456,147179,644150)) -> (10097+10096+10552+10095+10109+10094+10093+10092+81873) -> (60,71) |
Class |
|
Type |
Reference
|
Gene |
1950 | EGF; epidermal growth factor |
1956 | EGFR; epidermal growth factor receptor |
6714 | SRC; SRC proto-oncogene, non-receptor tyrosine kinase |
4690 | NCK1; NCK adaptor protein 1 |
8440 | NCK2; NCK adaptor protein 2 |
8976 | WASL; WASP like actin nucleation promoting factor |
7456 | WIPF1; WAS/WASL interacting protein family member 1 |
147179 | WIPF2; WAS/WASL interacting protein family member 2 |
644150 | WIPF3; WAS/WASL interacting protein family member 3 |
10097 | ACTR2; actin related protein 2 |
10096 | ACTR3; actin related protein 3 |
10552 | ARPC1A; actin related protein 2/3 complex subunit 1A |
10095 | ARPC1B; actin related protein 2/3 complex subunit 1B |
10109 | ARPC2; actin related protein 2/3 complex subunit 2 |
10094 | ARPC3; actin related protein 2/3 complex subunit 3 |
10093 | ARPC4; actin related protein 2/3 complex subunit 4 |
10092 | ARPC5; actin related protein 2/3 complex subunit 5 |
81873 | ARPC5L; actin related protein 2/3 complex subunit 5 like |
|
Reference |
|
Authors |
Reynolds AB, Kanner SB, Bouton AH, Schaller MD, Weed SA, Flynn DC, Parsons JT |
Title |
SRChing for the substrates of Src. |
Journal |
|
Reference |
|
Authors |
Tehrani S, Tomasevic N, Weed S, Sakowicz R, Cooper JA |
Title |
Src phosphorylation of cortactin enhances actin assembly. |
Journal |
|
Reference |
|
Authors |
Oser M, Mader CC, Gil-Henn H, Magalhaes M, Bravo-Cordero JJ, Koleske AJ, Condeelis J |
Title |
Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia. |
Journal |
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LinkDB |
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