| Entry |
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| Name |
TBK1-mediated autophagosome formation
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| Definition |
TBK1 -> (SQSTM1,OPTN,NDP52,TAX1BP1,NBR1) == LC3-II |
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| Expanded |
29110 -> (8878,10133,10241,8887,4077) == ((84557,81631,643246,440738)+C00350) |
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| Class |
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| Type |
Reference
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| Pathway |
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| Gene |
| 29110 | TBK1; TANK binding kinase 1 |
| 8878 | SQSTM1; sequestosome 1 |
| 10241 | CALCOCO2; calcium binding and coiled-coil domain 2 |
| 8887 | TAX1BP1; Tax1 binding protein 1 |
| 4077 | NBR1; NBR1 autophagy cargo receptor |
| 84557 | MAP1LC3A; microtubule associated protein 1 light chain 3 alpha |
| 81631 | MAP1LC3B; microtubule associated protein 1 light chain 3 beta |
| 643246 | MAP1LC3B2; microtubule associated protein 1 light chain 3 beta 2 |
| 440738 | MAP1LC3C; microtubule associated protein 1 light chain 3 gamma |
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| Metabolite |
| C00350 | Phosphatidylethanolamine |
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| Reference |
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| Authors |
Herhaus L, Dikic I |
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| Title |
Expanding the ubiquitin code through post-translational modification. |
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| Journal |
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| Reference |
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| Authors |
Kiriyama Y, Nochi H |
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| Title |
The Function of Autophagy in Neurodegenerative Diseases. |
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| Journal |
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| Reference |
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| Authors |
Richter B, Sliter DA, Herhaus L, Stolz A, Wang C, Beli P, Zaffagnini G, Wild P, Martens S, Wagner SA, Youle RJ, Dikic I |
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| Title |
Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria. |
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| Journal |
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| Reference |
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| Authors |
Matsumoto G, Shimogori T, Hattori N, Nukina N |
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| Title |
TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation. |
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| Journal |
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| LinkDB |
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