| Entry |
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| Name |
Scrapie conformation PrPSc to PERK-ATF4 signaling pathway
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| Definition |
PRNP* -| BIP -| EIF2AK3 -> EIF2S1 -> ATF4 => DDIT3 |
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| Expanded |
5621v1 -| 3309 -| 9451 -> 1965 -> 468 => 1649 |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
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| Gene |
| 3309 | HSPA5; heat shock protein family A (Hsp70) member 5 |
| 9451 | EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3 |
| 1965 | EIF2S1; eukaryotic translation initiation factor 2 subunit alpha |
| 468 | ATF4; activating transcription factor 4 |
| 1649 | DDIT3; DNA damage inducible transcript 3 |
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| Variant |
5621v1 (PRNP*) PRNP scrapie conformation
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| Reference |
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| Authors |
Hughes D, Mallucci GR |
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| Title |
The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway. |
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| Journal |
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| Reference |
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| Authors |
Halliday M, Hughes D, Mallucci GR |
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| Title |
Fine-tuning PERK signaling for neuroprotection. |
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| Journal |
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| Reference |
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| Authors |
Hughes D, Halliday M |
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| Title |
What Is Our Current Understanding of PrP(Sc)-Associated Neurotoxicity and Its Molecular Underpinnings? |
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| Journal |
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| Reference |
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| Authors |
Mays CE, Soto C |
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| Title |
The stress of prion disease. |
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| Journal |
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| Reference |
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| Authors |
Song Z, Zhao D, Yang L |
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| Title |
Molecular mechanisms of neurodegeneration mediated by dysfunctional subcellular organelles in transmissible spongiform encephalopathies. |
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| Journal |
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| LinkDB |
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