Entry |
|
Name |
Scrapie conformation PrPSc to mGluR5-Ca2+ -apoptotic pathway
|
Definition |
PRNP* -> (RYR,ITPR) -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> CASP3 |
Expanded |
5621v1 -> (6261,6262,6263,3708,3709,3710) -> C00076 -- 90550 -> C00076 -- (7416,7417,7419,291,292,293,83447) -> 54205 == 317 -> 842 -> 836 |
Class |
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Type |
Variant
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Pathway |
|
Disease |
|
Gene |
6261 | RYR1; ryanodine receptor 1 |
6262 | RYR2; ryanodine receptor 2 |
6263 | RYR3; ryanodine receptor 3 |
3708 | ITPR1; inositol 1,4,5-trisphosphate receptor type 1 |
3709 | ITPR2; inositol 1,4,5-trisphosphate receptor type 2 |
3710 | ITPR3; inositol 1,4,5-trisphosphate receptor type 3 |
90550 | MCU; mitochondrial calcium uniporter |
7416 | VDAC1; voltage dependent anion channel 1 |
7417 | VDAC2; voltage dependent anion channel 2 |
7419 | VDAC3; voltage dependent anion channel 3 |
291 | SLC25A4; solute carrier family 25 member 4 |
292 | SLC25A5; solute carrier family 25 member 5 |
293 | SLC25A6; solute carrier family 25 member 6 |
83447 | SLC25A31; solute carrier family 25 member 31 |
54205 | CYCS; cytochrome c, somatic |
317 | APAF1; apoptotic peptidase activating factor 1 |
|
Variant |
5621v1 (PRNP*) PRNP scrapie conformation
|
Metabolite |
|
Reference |
|
Authors |
Ferreiro E, Oliveira CR, Pereira CM |
Title |
The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway. |
Journal |
|
Reference |
|
Authors |
Ferreiro E, Resende R, Costa R, Oliveira CR, Pereira CM |
Title |
An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity. |
Journal |
|
Reference |
|
Authors |
Torres M, Encina G, Soto C, Hetz C |
Title |
Abnormal calcium homeostasis and protein folding stress at the ER: A common factor in familial and infectious prion disorders. |
Journal |
|
Reference |
|
Authors |
Hetz C, Mollereau B |
Title |
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases. |
Journal |
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LinkDB |
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