KEGG   NETWORK: N01201
Entry
N01201                      Network                                
Name
Scrapie conformation PrPSc to VGCC-Ca2+ -apoptotic pathway
Definition
PRNP* -| VGCC(N,L-type) -> Ca2+
  Expanded
5621v1 -| (774,775,776,778,779) -> C00076
Class
nt06465 Prion disease
nt06466 Pathways of neurodegeneration
Type
Variant
Pathway
hsa05020  Prion disease
Disease
H00061  Prion disease
Gene
5621  PRNP; prion protein
774  CACNA1B; calcium voltage-gated channel subunit alpha1 B
775  CACNA1C; calcium voltage-gated channel subunit alpha1 C
776  CACNA1D; calcium voltage-gated channel subunit alpha1 D
778  CACNA1F; calcium voltage-gated channel subunit alpha1 F
779  CACNA1S; calcium voltage-gated channel subunit alpha1 S
Variant
5621v1 (PRNP*)  PRNP scrapie conformation
Metabolite
C00076  Calcium cation
Reference
PMID:31795242
  Authors
Ureshino RP, Erustes AG, Bassani TB, Wachilewski P, Guarache GC, Nascimento AC, Costa AJ, Smaili SS, Pereira GJDS
  Title
The Interplay between Ca(2+) Signaling Pathways and Neurodegeneration.
  Journal
Int J Mol Sci 20:E6004 (2019)
DOI:10.3390/ijms20236004
Reference
PMID:10964602
  Authors
Thellung S, Florio T, Villa V, Corsaro A, Arena S, Amico C, Robello M, Salmona M, Forloni G, Bugiani O, Tagliavini F, Schettini G
  Title
Apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in rat cerebellar granule cells treated with the prion protein fragment  106-126.
  Journal
Neurobiol Dis 7:299-309 (2000)
DOI:10.1006/nbdi.2000.0301
Reference
PMID:14751779
  Authors
Sandberg MK, Wallen P, Wikstrom MA, Kristensson K
  Title
Scrapie-infected GT1-1 cells show impaired function of voltage-gated N-type calcium channels (Ca(v) 2.2) which is ameliorated by quinacrine treatment.
  Journal
Neurobiol Dis 15:143-51 (2004)
DOI:10.1016/j.nbd.2003.09.006
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