KEGG   NETWORK: N01314
Entry
N01314                      Network                                
Name
SARS-CoV-2 S to classical pathway of complement cascade
Definition
S -> (IgG,IgM) -> ((C1QA,C1QB,C1QC)+C1R+C1S))
  Expanded
K24152 -> 102723407 -> ((712,713,714)+715+716))
Class
nt06513 Complement cascade
nt06171 SARS coronavirus 2 (SARS-CoV-2)
Type
Pathogen
Pathway
hsa05171  Coronavirus disease - COVID-19
Disease
H02398  COVID-19
Gene
102723407  IGH; immunoglobulin heavy variable 4-38-2-like
712  C1QA; complement C1q A chain
713  C1QB; complement C1q B chain
714  C1QC; complement C1q C chain
715  C1R; complement C1r
716  C1S; complement C1s
Perturbant
K24152 (S)  S; SARS coronavirus spike glycoprotein
Reference
  Authors
Noris M, Benigni A, Remuzzi G
  Title
The case of complement activation in COVID-19 multiorgan impact.
  Journal
Kidney Int 98:314-322 (2020)
DOI:10.1016/j.kint.2020.05.013
Reference
  Authors
Jodele S, Kohl J
  Title
Tackling COVID-19 infection through complement-targeted immunotherapy.
  Journal
Br J Pharmacol 178:2832-2848 (2021)
DOI:10.1111/bph.15187
Reference
  Authors
Chauhan AJ, Wiffen LJ, Brown TP
  Title
COVID-19: A collision of complement, coagulation and inflammatory pathways.
  Journal
J Thromb Haemost 18:2110-2117 (2020)
DOI:10.1111/jth.14981
LinkDB

DBGET integrated database retrieval system