Entry |
|
Name |
EP/NE-ADRB-cAMP signaling pathway
|
Definition |
(EP,NE) -> ADRB2 -> GNAS -> ADCY -> cAMP -> PKA -> PLN |
Expanded |
(C00788,C00547) -> 154 -> 2778 -> (107,108,109,196883,111,112,113,114,115) -> C00575 -> (5566+5567+5568) -> 5350 |
Class |
|
Type |
Reference
|
Pathway |
hsa04261 | Adrenergic signaling in cardiomyocytes |
|
Gene |
154 | ADRB2; adrenoceptor beta 2 |
2778 | GNAS; GNAS complex locus |
107 | ADCY1; adenylate cyclase 1 |
108 | ADCY2; adenylate cyclase 2 |
109 | ADCY3; adenylate cyclase 3 |
196883 | ADCY4; adenylate cyclase 4 |
111 | ADCY5; adenylate cyclase 5 |
112 | ADCY6; adenylate cyclase 6 |
113 | ADCY7; adenylate cyclase 7 |
114 | ADCY8; adenylate cyclase 8 |
115 | ADCY9; adenylate cyclase 9 |
5566 | PRKACA; protein kinase cAMP-activated catalytic subunit alpha |
5567 | PRKACB; protein kinase cAMP-activated catalytic subunit beta |
5568 | PRKACG; protein kinase cAMP-activated catalytic subunit gamma |
|
Metabolite |
|
Reference |
|
Authors |
Wallukat G |
Title |
The beta-adrenergic receptors. |
Journal |
|
Reference |
|
Authors |
Lohse MJ, Engelhardt S, Eschenhagen T |
Title |
What is the role of beta-adrenergic signaling in heart failure? |
Journal |
|
Reference |
|
Authors |
Spadari RC, Cavadas C, de Carvalho AETS, Ortolani D, de Moura AL, Vassalo PF |
Title |
Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress. |
Journal |
|
LinkDB |
|