KEGG   NETWORK: N01356
Entry
N01356                      Network                                
Name
Membrane-initiated progesterone signaling pathway
Definition
P4 -> mPR -> PI3K -> PIP3 -> AKT
  Expanded
C00410 -> (164091,85315,54852) -> (5290,5291,5293) -> C05981 -> (207,208,10000)
Class
nt06214 PI3K signaling (cancer)
Type
Reference
Gene
164091  PAQR7; progestin and adipoQ receptor family member 7
85315  PAQR8; progestin and adipoQ receptor family member 8
54852  PAQR5; progestin and adipoQ receptor family member 5
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
Perturbant
C00410 (P4)  Progesterone
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:29146555
  Authors
Boonyaratanakornkit V, Hamilton N, Marquez-Garban DC, Pateetin P, McGowan EM, Pietras RJ
  Title
Extranuclear signaling by sex steroid receptors and clinical implications in breast cancer.
  Journal
Mol Cell Endocrinol 466:51-72 (2018)
DOI:10.1016/j.mce.2017.11.010
Reference
PMID:32867363
  Authors
Pedroza DA, Subramani R, Lakshmanaswamy R
  Title
Classical and Non-Classical Progesterone Signaling in Breast Cancers.
  Journal
Cancers (Basel) 12:E2440 (2020)
DOI:10.3390/cancers12092440
Reference
PMID:18343488
  Authors
Thomas P
  Title
Characteristics of membrane progestin receptor alpha (mPRalpha) and progesterone membrane receptor component 1 (PGMRC1) and their roles in mediating rapid progestin actions.
  Journal
Front Neuroendocrinol 29:292-312 (2008)
DOI:10.1016/j.yfrne.2008.01.001
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