| Entry |
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| Name |
P4/MPA to nuclear-initiated progesterone signaling pathway
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| Definition |
(P4,MPA) -> PGR => (WNT1,NOTCH2,JAG1) |
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| Expanded |
(C00410,C08150) -> 5241 => (7471,4853,182) |
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| Class |
nt06227 Nuclear receptor signaling (cancer)
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| Type |
Env factor
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| Pathway |
| hsa05207 | Chemical carcinogenesis - receptor activation |
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| Disease |
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| Gene |
| 5241 | PGR; progesterone receptor |
| 7471 | WNT1; Wnt family member 1 |
| 4853 | NOTCH2; notch receptor 2 |
| 182 | JAG1; jagged canonical Notch ligand 1 |
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| Perturbant |
| C08150 (MPA) | Medroxyprogesterone acetate |
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| Reference |
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| Authors |
Pedroza DA, Subramani R, Lakshmanaswamy R |
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| Title |
Classical and Non-Classical Progesterone Signaling in Breast Cancers. |
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| Journal |
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| Reference |
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| Authors |
Finlay-Schultz J, Sartorius CA |
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| Title |
Steroid hormones, steroid receptors, and breast cancer stem cells. |
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| Journal |
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| Reference |
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| Authors |
Chen B, Ye P, Chen Y, Liu T, Cha JH, Yan X, Yang WH |
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| Title |
Involvement of the Estrogen and Progesterone Axis in Cancer Stemness: Elucidating Molecular Mechanisms and Clinical Significance. |
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| Journal |
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| Reference |
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| Authors |
Asi N, Mohammed K, Haydour Q, Gionfriddo MR, Vargas OL, Prokop LJ, Faubion SS, Murad MH |
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| Title |
Progesterone vs. synthetic progestins and the risk of breast cancer: a systematic review and meta-analysis. |
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| Journal |
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| LinkDB |
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