NETWORK: N01365
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Entry
N01365 Network
Name
TCDD to Ahr signaling pathway
Definition
TCDD -> (AHR+ARNT) => (CYP1A1,
CYP1B1,
GST)
Expanded
C07557 -> (196+405) => (1543,
1545,
(119391,
221357,
2938,
2939,
2940,
2941,
2944,
2946,
2947,
2948,
2949,
2950,
2952,
2953,
4257,
4258,
4259,
653689,
9446))
Class
nt06227
Nuclear receptor signaling (cancer)
Type
Env factor
Pathway
hsa05207
Chemical carcinogenesis - receptor activation
Disease
H00048
Hepatocellular carcinoma
H00014
Non-small cell lung cancer
Gene
196
AHR; aryl hydrocarbon receptor
405
ARNT; aryl hydrocarbon receptor nuclear translocator
1543
CYP1A1; cytochrome P450 family 1 subfamily A member 1
1545
CYP1B1; cytochrome P450 family 1 subfamily B member 1
119391
GSTO2; glutathione S-transferase omega 2
221357
GSTA5; glutathione S-transferase alpha 5
2938
GSTA1; glutathione S-transferase alpha 1
2939
GSTA2; glutathione S-transferase alpha 2
2940
GSTA3; glutathione S-transferase alpha 3
2941
GSTA4; glutathione S-transferase alpha 4
2944
GSTM1; glutathione S-transferase mu 1
2946
GSTM2; glutathione S-transferase mu 2
2947
GSTM3; glutathione S-transferase mu 3
2948
GSTM4; glutathione S-transferase mu 4
2949
GSTM5; glutathione S-transferase mu 5
2950
GSTP1; glutathione S-transferase pi 1
2952
GSTT1; glutathione S-transferase theta 1
2953
GSTT2; glutathione S-transferase theta 2 (gene/pseudogene)
4257
MGST1; microsomal glutathione S-transferase 1
4258
MGST2; microsomal glutathione S-transferase 2
4259
MGST3; microsomal glutathione S-transferase 3
653689
GSTT2B; glutathione S-transferase theta 2B
9446
GSTO1; glutathione S-transferase omega 1
Perturbant
C07557
(TCDD)
2,3,7,8-Tetrachlorodibenzodioxin
Reference
PMID:
15900503
Authors
Mandal PK
Title
Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology.
Journal
J Comp Physiol B 175:221-30 (2005)
DOI:
10.1007/s00360-005-0483-3
Reference
PMID:
15660110
Authors
Luch A.
Title
Nature and nurture - lessons from chemical carcinogenesis.
Journal
Nat Rev Cancer 5:113-25 (2005)
DOI:
10.1038/nrc1546
Reference
PMID:
31552251
Authors
Hidaka T, Fujimura T, Aiba S
Title
Aryl Hydrocarbon Receptor Modulates Carcinogenesis and Maintenance of Skin Cancers.
Journal
Front Med (Lausanne) 6:194 (2019)
DOI:
10.3389/fmed.2019.00194
Reference
PMID:
12573486
Authors
Mimura J, Fujii-Kuriyama Y
Title
Functional role of AhR in the expression of toxic effects by TCDD.
Journal
Biochim Biophys Acta 1619:263-8 (2003)
DOI:
10.1016/s0304-4165(02)00485-3
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