KEGG   NETWORK: N01372
Entry
N01372                      Network                                
Name
IQ to DNA adducts
Definition
IQ -- CYP1A2 >> (NAT1,NAT2) -> N-Acetoxy-IQ == DNA
  Expanded
C19180 -- 1544 >> (9,10) -> C20290 == C00039
Class
nt06250 DNA adduct formation (cancer)
Type
Env factor
Pathway
hsa05204  Chemical carcinogenesis - DNA adducts
Disease
H00031  Breast cancer
Gene
1544  CYP1A2; cytochrome P450 family 1 subfamily A member 2
9  NAT1; N-acetyltransferase 1
10  NAT2; N-acetyltransferase 2
Perturbant
C19180 (IQ)  2-Amino-3-methylimidazo[4,5-f]quinoline
Metabolite
C20290  N-Acetoxy-IQ
C00039  DNA
Reference
  Authors
Immonen E, Kummu M, Petsalo A, Pihlaja T, Mathiesen L, Nielsen JK, Knudsen LE, Vahakangas K, Myllynen P
  Title
Toxicokinetics of the food-toxin IQ in human placental perfusion is not affected by ABCG2 or xenobiotic metabolism.
  Journal
Placenta 31:641-8 (2010)
DOI:10.1016/j.placenta.2010.05.002
Reference
  Authors
Metry KJ, Neale JR, Doll MA, Howarth AL, States JC, McGregor WG, Pierce WM Jr, Hein DW
  Title
Effect of rapid human N-acetyltransferase 2 haplotype on DNA damage and mutagenesis induced by 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx).
  Journal
Mutat Res 684:66-73 (2010)
DOI:10.1016/j.mrfmmm.2009.12.001
Reference
  Authors
Williams JA, Stone EM, Millar BC, Hewer A, Phillips DH
  Title
Pathways of heterocyclic amine activation in the breast: DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) formed by peroxidases and in human mammary epithelial cells and fibroblasts.
  Journal
Mutagenesis 15:149-54 (2000)
DOI:10.1093/mutage/15.2.149
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