Entry Name Definition BaP -- (CYP1A1,CYP1B1) >> EPHX1 >> (CYP1A1,CYP1B1) -> BPDE == DNA
Expanded C07535 -- (1543,1545) >> 2052 >> (1543,1545) -> C14853 == C00039
Class nt06250 DNA adduct formation (cancer)
Type Env factor
Pathway hsa05204 Chemical carcinogenesis - DNA adducts
Disease H00040 Squamous cell carcinoma
H00014 Non-small cell lung cancer
Gene 1543 CYP1A1; cytochrome P450 family 1 subfamily A member 1
1545 CYP1B1; cytochrome P450 family 1 subfamily B member 1
2052 EPHX1; epoxide hydrolase 1
Perturbant Metabolite C14853 Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide
Reference Authors Luch A.
Title Nature and nurture - lessons from chemical carcinogenesis.
Journal Reference Authors Singh R, Sram RJ, Binkova B, Kalina I, Popov TA, Georgieva T, Garte S, Taioli E, Farmer PB
Title The relationship between biomarkers of oxidative DNA damage, polycyclic aromatic hydrocarbon DNA adducts, antioxidant status and genetic susceptibility following exposure to environmental air pollution in humans.
Journal Reference Authors Lodovici M, Luceri C, Guglielmi F, Bacci C, Akpan V, Fonnesu ML, Boddi V, Dolara P.
Title Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH.
Journal Cancer Epidemiol Biomarkers Prev 13:1342-8 (2004)
Reference Authors Li D, Wang LE, Chang P, El-Naggar AK, Sturgis EM, Wei Q
Title In vitro benzo[a]pyrene diol epoxide-induced DNA adducts and risk of squamous cell carcinoma of head and neck.
Journal LinkDB All DBs
