Entry Name Definition DMBA -- CYP1A1 >> EPHX1 >> CYP1A1 -> DMBADE == DNA
Expanded C19488 -- 1543 >> 2052 >> 1543 -> C19559 == C00039
Class nt06250 DNA adduct formation (cancer)
Type Env factor
Pathway hsa05204 Chemical carcinogenesis - DNA adducts
Disease Gene 1543 CYP1A1; cytochrome P450 family 1 subfamily A member 1
2052 EPHX1; epoxide hydrolase 1
Perturbant C19488 (DMBA) 7,12-Dimethylbenz[a]anthracene
Metabolite C19559 (1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol
Reference Authors Androutsopoulos VP, Tsatsakis AM, Spandidos DA
Title Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention.
Journal Reference Authors Gonzalez FJ, Kimura S
Title Understanding the role of xenobiotic-metabolism in chemical carcinogenesis using gene knockout mice.
Journal Reference Authors Melendez-Colon VJ, Luch A, Seidel A, Baird WM
Title Cancer initiation by polycyclic aromatic hydrocarbons results from formation of stable DNA adducts rather than apurinic sites.
Journal Reference Authors Arif JM, Smith WA, Gupta RC
Title Tissue distribution of DNA adducts in rats treated by intramammillary injection with dibenzo[a,l]pyrene, 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene.
Journal Reference Authors Ledet MM, Oswald M, Anderson R, Van de Walle GR
Title Differential signaling pathway activation in 7,12-dimethylbenz[a] anthracene (DMBA)-treated mammary stem/progenitor cells from species with varying mammary cancer incidence.
Journal LinkDB All DBs
