KEGG   NETWORK: N01386
Entry
N01386                      Network                                
Name
DCE to DNA adducts
Definition
DCE -- GST -> C20304 -> C14874 == DNA
  Expanded
C06752 -- (119391,221357,2938,2939,2940,2941,2944,2946,2947,2948,2949,2950,2952,2953,4257,4258,4259,653689,9446) -> C20304 -> C14874 == C00039
Class
nt06250 DNA adduct formation (cancer)
Type
Env factor
Pathway
hsa05204  Chemical carcinogenesis - DNA adducts
Disease
H01557  Hepatic angiosarcoma
H00031  Breast cancer
Gene
119391  GSTO2; glutathione S-transferase omega 2
221357  GSTA5; glutathione S-transferase alpha 5
2938  GSTA1; glutathione S-transferase alpha 1
2939  GSTA2; glutathione S-transferase alpha 2
2940  GSTA3; glutathione S-transferase alpha 3
2941  GSTA4; glutathione S-transferase alpha 4
2944  GSTM1; glutathione S-transferase mu 1
2946  GSTM2; glutathione S-transferase mu 2
2947  GSTM3; glutathione S-transferase mu 3
2948  GSTM4; glutathione S-transferase mu 4
2949  GSTM5; glutathione S-transferase mu 5
2950  GSTP1; glutathione S-transferase pi 1
2952  GSTT1; glutathione S-transferase theta 1
2953  GSTT2; glutathione S-transferase theta 2 (gene/pseudogene)
4257  MGST1; microsomal glutathione S-transferase 1
4258  MGST2; microsomal glutathione S-transferase 2
4259  MGST3; microsomal glutathione S-transferase 3
653689  GSTT2B; glutathione S-transferase theta 2B
9446  GSTO1; glutathione S-transferase omega 1
Perturbant
C06752 (DCE)  1,2-Dichloroethane
Metabolite
C20304  S-(2-Chloroethyl)glutathione
C14874  Glutathione episulfonium ion
C00039  DNA
Reference
PMID:21255676
  Authors
Gwinn MR, Johns DO, Bateson TF, Guyton KZ
  Title
A review of the genotoxicity of 1,2-dichloroethane (EDC).
  Journal
Mutat Res 727:42-53 (2011)
DOI:10.1016/j.mrrev.2011.01.001
Reference
PMID:15660110
  Authors
Luch A.
  Title
Nature and nurture - lessons from chemical carcinogenesis.
  Journal
Nat Rev Cancer 5:113-25 (2005)
DOI:10.1038/nrc1546
Reference
PMID:27308968
  Authors
Myers JL
  Title
Development of an inhalation unit risk factor for ethylene dichloride.
  Journal
Inhal Toxicol 28:403-9 (2016)
DOI:10.1080/08958378.2016.1188187
Reference
PMID:2053843
  Authors
Baertsch A, Lutz WK, Schlatter C
  Title
Effect of inhalation exposure regimen on DNA binding potency of 1,2-dichloroethane in the rat.
  Journal
Arch Toxicol 65:169-76 (1991)
DOI:10.1007/BF02307305
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