KEGG   NETWORK: N01391
Entry
N01391                      Network                                
Name
Lead to SOD/Cat-mediated ROS neutralization
Definition
Pb -| CAT
  Expanded
C06696 -| 847
Class
nt06253 Antioxidant system (cancer)
Type
Env factor
Pathway
hsa05208  Chemical carcinogenesis - reactive oxygen species
Disease
H00018  Gastric cancer
Gene
847  CAT; catalase
Perturbant
C06696 (Pb)  Lead
Reference
  Authors
Lee JC, Son YO, Pratheeshkumar P, Shi X
  Title
Oxidative stress and metal carcinogenesis.
  Journal
Free Radic Biol Med 53:742-57 (2012)
DOI:10.1016/j.freeradbiomed.2012.06.002
Reference
  Authors
El-Sayed IH, Lotfy M, El-Khawaga OA, Nasif WA, El-Shahat M
  Title
Prominent free radicals scavenging activity of tannic acid in lead-induced oxidative stress in experimental mice.
  Journal
Toxicol Ind Health 22:157-63 (2006)
DOI:10.1191/0748233706th256oa
Reference
  Authors
Gurer H, Ercal N
  Title
Can antioxidants be beneficial in the treatment of lead poisoning?
  Journal
Free Radic Biol Med 29:927-45 (2000)
DOI:10.1016/s0891-5849(00)00413-5
Reference
  Authors
Zhao Q, Wang Y, Cao Y, Chen A, Ren M, Ge Y, Yu Z, Wan S, Hu A, Bo Q, Ruan L, Chen H, Qin S, Chen W, Hu C, Tao F, Xu D, Xu J, Wen L, Li L
  Title
Potential health risks of heavy metals in cultivated topsoil and grain, including correlations with human primary liver, lung and gastric cancer, in Anhui province, Eastern China.
  Journal
Sci Total Environ 470-471:340-7 (2014)
DOI:10.1016/j.scitotenv.2013.09.086
Reference
  Authors
Yuan W, Yang N, Li X
  Title
Advances in Understanding How Heavy Metal Pollution Triggers Gastric Cancer.
  Journal
Biomed Res Int 2016:7825432 (2016)
DOI:10.1155/2016/7825432
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