KEGG   NETWORK: N01440
Entry
N01440                      Network                                
Name
Wnt signaling modulation, LGR/RSPO
Definition
(RSPO+LGR4/5/6)) -| (ZNRF3,RNF43) -| FZD
  Expanded
((284654,340419,84870,343637)+(55366,8549,59352)) -| (84133,54894) -| (8321,2535,7976,8322,7855,8323,8324,8325,8326,11211)
Class
nt06505 WNT signaling
Type
Reference
Pathway
hsa04310  Wnt signaling pathway
Gene
284654  RSPO1; R-spondin 1
340419  RSPO2; R-spondin 2
84870  RSPO3; R-spondin 3
343637  RSPO4; R-spondin 4
55366  LGR4; leucine rich repeat containing G protein-coupled receptor 4
8549  LGR5; leucine rich repeat containing G protein-coupled receptor 5
59352  LGR6; leucine rich repeat containing G protein-coupled receptor 6
84133  ZNRF3; zinc and ring finger 3
54894  RNF43; ring finger protein 43
8321  FZD1; frizzled class receptor 1
2535  FZD2; frizzled class receptor 2
7976  FZD3; frizzled class receptor 3
8322  FZD4; frizzled class receptor 4
7855  FZD5; frizzled class receptor 5
8323  FZD6; frizzled class receptor 6
8324  FZD7; frizzled class receptor 7
8325  FZD8; frizzled class receptor 8
8326  FZD9; frizzled class receptor 9
11211  FZD10; frizzled class receptor 10
Reference
PMID:35052478
  Authors
Martinez-Gil N, Ugartondo N, Grinberg D, Balcells S
  Title
Wnt Pathway Extracellular Components and Their Essential Roles in Bone Homeostasis.
  Journal
Genes (Basel) 13:138 (2022)
DOI:10.3390/genes13010138
Reference
PMID:32666024
  Authors
Doherty L, Sanjay A
  Title
LGRs in Skeletal Tissues: An Emerging Role for Wnt-Associated Adult Stem Cell Markers in Bone.
  Journal
JBMR Plus 4:e10380 (2020)
DOI:10.1002/jbm4.10380
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