KEGG   NETWORK: N01468
Entry
N01468                      Network                                
Name
DNA replication licensing
Definition
ORC == CDC6 == CDT1 == MCM -> pre-RC+DDK == CDC45+TICRR+MTBP == CDK
  Expanded
4998+4999+23595+5000+5001+23594 == 990 == 81620 == 4171+4172+4173+4174+4175+4176 -> 4998+4999+23595+5000+5001+23594+990+81620+4171+4172+4173+4174+4175+4176+10926+8317 == 8318+90381+27085 == 1017+(8900,890,898,9134)
Class
nt06509 DNA replication
Type
Reference
Pathway
hsa04110  Cell cycle
Gene
4998  ORC1; origin recognition complex subunit 1
4999  ORC2; origin recognition complex subunit 2
23595  ORC3; origin recognition complex subunit 3
5000  ORC4; origin recognition complex subunit 4
5001  ORC5; origin recognition complex subunit 5
23594  ORC6; origin recognition complex subunit 6
990  CDC6; cell division cycle 6
81620  CDT1; chromatin licensing and DNA replication factor 1
4171  MCM2; minichromosome maintenance complex component 2
4172  MCM3; minichromosome maintenance complex component 3
4173  MCM4; minichromosome maintenance complex component 4
4174  MCM5; minichromosome maintenance complex component 5
4175  MCM6; minichromosome maintenance complex component 6
4176  MCM7; minichromosome maintenance complex component 7
10926  DBF4; DBF4 zinc finger
8317  CDC7; cell division cycle 7
8318  CDC45; cell division cycle 45
90381  TICRR; TOPBP1 interacting checkpoint and replication regulator
27085  MTBP; MDM2 binding protein
1017  CDK2; cyclin dependent kinase 2
8900  CCNA1; cyclin A1
890  CCNA2; cyclin A2
898  CCNE1; cyclin E1
9134  CCNE2; cyclin E2
Reference
PMID:27006277
  Authors
Araki H
  Title
Elucidating the DDK-dependent step in replication initiation.
  Journal
EMBO J 35:907-8 (2016)
DOI:10.15252/embj.201694227
Reference
PMID:21729781
  Authors
Heller RC, Kang S, Lam WM, Chen S, Chan CS, Bell SP
  Title
Eukaryotic origin-dependent DNA replication in vitro reveals sequential action of DDK and S-CDK kinases.
  Journal
Cell 146:80-91 (2011)
DOI:10.1016/j.cell.2011.06.012
Reference
PMID:35741449
  Authors
Tanaka S, Ogawa S
  Title
Dimerization of Firing Factors for Replication Origin Activation in Eukaryotes: A Crucial Process for Simultaneous Assembly of Bidirectional Replication Forks?
  Journal
Biology (Basel) 11:928 (2022)
DOI:10.3390/biology11060928
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