KEGG   NETWORK: N01502
Entry
N01502                      Network                                
Name
Lectin pathway of coagulation cascade, fibrinogen to fibrin
Definition
FG -- (F2a,((MBL2,COLEC10/11,FCN)+MASP1)) -> Fibrin
  Expanded
(2243,2244,2266) -- (C00752,((4153,(10584,78989),(2219,2220,8547))+5648)) -> C00290
Class
nt06171 SARS coronavirus 2 (SARS-CoV-2)
Type
Reference
Gene
2243  FGA; fibrinogen alpha chain
2244  FGB; fibrinogen beta chain
2266  FGG; fibrinogen gamma chain
4153  MBL2; mannose binding lectin 2
10584  COLEC10; collectin subfamily member 10
78989  COLEC11; collectin subfamily member 11
2219  FCN1; ficolin 1
2220  FCN2; ficolin 2
8547  FCN3; ficolin 3
5648  MASP1; MBL associated serine protease 1
Metabolite
C00752  Thrombin
C00290  Fibrin
Reference
  Authors
Krarup A, Wallis R, Presanis JS, Gal P, Sim RB
  Title
Simultaneous activation of complement and coagulation by MBL-associated serine protease 2.
  Journal
PLoS One 2:e623 (2007)
DOI:10.1371/journal.pone.0000623
Reference
  Authors
Wiegner R, Chakraborty S, Huber-Lang M
  Title
Complement-coagulation crosstalk on cellular and artificial surfaces.
  Journal
Immunobiology 221:1073-9 (2016)
DOI:10.1016/j.imbio.2016.06.005
Reference
  Authors
Hess K, Ajjan R, Phoenix F, Dobo J, Gal P, Schroeder V
  Title
Effects of MASP-1 of the complement system on activation of coagulation factors and plasma clot formation.
  Journal
PLoS One 7:e35690 (2012)
DOI:10.1371/journal.pone.0035690
Reference
  Authors
Gulla KC, Gupta K, Krarup A, Gal P, Schwaeble WJ, Sim RB, O'Connor CD, Hajela K
  Title
Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot.
  Journal
Immunology 129:482-95 (2010)
DOI:10.1111/j.1365-2567.2009.03200.x
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