KEGG   NETWORK: N01538
Entry
N01538                      Network                                
Name
Hedgehog signaling pathway, PTCH coreceptor
Definition
((CDON,BOC),GAS1,LRP2) -> (HH+PTCH)
  Expanded
((50937,91653),2619,4036) -> ((6469,3549,50846)+(5727,8643))
Class
nt06501 HH signaling
Type
Reference
Pathway
hsa04340  Hedgehog signaling pathway
Gene
50937  CDON; cell adhesion associated, oncogene regulated
91653  BOC; BOC cell adhesion associated, oncogene regulated
2619  GAS1; growth arrest specific 1
4036  LRP2; LDL receptor related protein 2
6469  SHH; sonic hedgehog signaling molecule
3549  IHH; Indian hedgehog signaling molecule
50846  DHH; desert hedgehog signaling molecule
5727  PTCH1; patched 1
8643  PTCH2; patched 2
Reference
  Authors
Wierbowski BM, Petrov K, Aravena L, Gu G, Xu Y, Salic A
  Title
Hedgehog Pathway Activation Requires Coreceptor-Catalyzed, Lipid-Dependent Relay of the Sonic Hedgehog Ligand.
  Journal
Dev Cell 55:450-467.e8 (2020)
DOI:10.1016/j.devcel.2020.09.017
Reference
  Authors
Christ A, Herzog K, Willnow TE
  Title
LRP2, an auxiliary receptor that controls sonic hedgehog signaling in development and disease.
  Journal
Dev Dyn 245:569-79 (2016)
DOI:10.1002/dvdy.24394
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