KEGG   NETWORK: N01541
Entry
N01541                      Network                                
Name
Testosterone biosynthesis
Definition
Pregnenolone -- CYP17A1 >> HSD3B1/2 -> Androstenedione -- (AKR1C3,HSD17B) -> T -- SRD5A -> DHT
  Expanded
C01953 -- 1586 >> (3283,3284) -> C00280 -- (8644,3293,3294,7923,8630) -> C00535 -- (6715,6716,79644) -> C03917
Class
nt06019 Steroid hormone biosynthesis
Type
Reference
Pathway
hsa00140  Steroid hormone biosynthesis
Gene
1586  CYP17A1; cytochrome P450 family 17 subfamily A member 1
3283  HSD3B1; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
3284  HSD3B2; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
8644  AKR1C3; aldo-keto reductase family 1 member C3
3293  HSD17B3; hydroxysteroid 17-beta dehydrogenase 3
3294  HSD17B2; hydroxysteroid 17-beta dehydrogenase 2
7923  HSD17B8; hydroxysteroid 17-beta dehydrogenase 8
8630  HSD17B6; hydroxysteroid 17-beta dehydrogenase 6
6715  SRD5A1; steroid 5 alpha-reductase 1
6716  SRD5A2; steroid 5 alpha-reductase 2
79644  SRD5A3; steroid 5 alpha-reductase 3
Metabolite
C01953  Pregnenolone
C00280  Androstenedione
C00535  Testosterone
C03917  Dihydrotestosterone
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