KEGG   NETWORK: N01582
Entry
N01582                      Network                                
Name
Heparan sulfate biosynthesis
Definition
G00157 -- EXTL2/3 >> EXT1/2 >> EXTL1/3 >> NDST >> GLCE >> HS6ST1 -> Heparan_sulfate
  Expanded
G00157 -- (2135,2137) >> (2131,2132) >> (2134,2137) >> (3340,8509,9348,64579) >> 26035 >> 9394 -> C00925
Class
nt06029 Glycosaminoglycan biosynthesis
Type
Reference
Pathway
hsa00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
Gene
2135  EXTL2; exostosin like glycosyltransferase 2
2137  EXTL3; exostosin like glycosyltransferase 3
2131  EXT1; exostosin glycosyltransferase 1
2132  EXT2; exostosin glycosyltransferase 2
2134  EXTL1; exostosin like glycosyltransferase 1
3340  NDST1; N-deacetylase and N-sulfotransferase 1
8509  NDST2; N-deacetylase and N-sulfotransferase 2
9348  NDST3; N-deacetylase and N-sulfotransferase 3
64579  NDST4; N-deacetylase and N-sulfotransferase 4
26035  GLCE; glucuronic acid epimerase
9394  HS6ST1; heparan sulfate 6-O-sulfotransferase 1
Metabolite
G00157   
C00925  Heparan sulfate
Reference
  Authors
Mizumoto S, Yamada S
  Title
Congenital Disorders of Deficiency in Glycosaminoglycan Biosynthesis.
  Journal
Front Genet 12:717535 (2021)
DOI:10.3389/fgene.2021.717535
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