NETWORK: N01659
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Entry
N01659 Network
Name
Lewis b antigen biosynthesis
Definition
TypeIH -- FUT3*Le -> Leb
Expanded
G00044 -- 2525v1 -> G00045
Class
nt06035
Blood group carbohydrate antigen biosynthesis
Type
Reference
Pathway
hsa00601
Glycosphingolipid biosynthesis - lacto and neolacto series
Gene
2525
FUT3; fucosyltransferase 3 (Lewis blood group)
Variant
2525v1
(FUT3*Le) FUT3 Le allele
Metabolite
G00044
IV2Fuc-Lc4Cer
G00045
IV2Fuc,III4Fuc-Lc4Cer
Reference
PMID:
36691627
Authors
Jajosky RP, Wu SC, Zheng L, Jajosky AN, Jajosky PG, Josephson CD, Hollenhorst MA, Sackstein R, Cummings RD, Arthur CM, Stowell SR
Title
ABO blood group antigens and differential glycan expression: Perspective on the evolution of common human enzyme deficiencies.
Journal
iScience 26:105798 (2023)
DOI:
10.1016/j.isci.2022.105798
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