KEGG   NETWORK: N01764
Entry
N01764                      Network                                
Name
Calreticulin-LRP1 mediated recognition and engulfment
Definition
CALR -> LRP1,(C1QA,C1QB,C1QC) -> GULP1
  Expanded
811 -> 4035,(712,713,714) -> 51454
Class
nt06535 Efferocytosis
Type
Reference
Pathway
hsa04148  Efferocytosis
Gene
811  CALR; calreticulin
4035  LRP1; LDL receptor related protein 1
712  C1QA; complement C1q A chain
713  C1QB; complement C1q B chain
714  C1QC; complement C1q C chain
51454  GULP1; GULP PTB domain containing engulfment adaptor 1
Reference
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
  Authors
Osman R, Tacnet-Delorme P, Kleman JP, Millet A, Frachet P
  Title
Calreticulin Release at an Early Stage of Death Modulates the Clearance by Macrophages of Apoptotic Cells.
  Journal
Front Immunol 8:1034 (2017)
DOI:10.3389/fimmu.2017.01034
Reference
  Authors
Wahler A, Beyer AS, Keller IE, Schnack C, von Einem B, Propper C, Boeckers TM, Peltan ID, Strickland DK, Hyman BT, von Arnim CA
  Title
Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together  with low-density lipoprotein receptor-related protein 1 (LRP1).
  Journal
Biochem J 450:333-43 (2013)
DOI:10.1042/BJ20121100
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