KEGG   NETWORK: N01777
Entry
N01777                      Network                                
Name
Efferocytosis-induced NAD production
Definition
FA(cyto) -- CPT1 -> FA(mt) -> RISP+NADH -> NAD
  Expanded
C00162 -- 1374,1375 -> C00162 -> 7386+C00004 -> C00003
Class
nt06535 Efferocytosis
Type
Reference
Pathway
hsa04148 Efferocytosis   
Gene
1374  CPT1A; carnitine palmitoyltransferase 1A
1375  CPT1B; carnitine palmitoyltransferase 1B
7386  UQCRFS1; ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
Metabolite
C00162  Fatty acid
C00004  NADH
C00003  NAD+
Reference
  Authors
Zhang S, Weinberg S, DeBerge M, Gainullina A, Schipma M, Kinchen JM, Ben-Sahra I, Gius DR, Yvan-Charvet L, Chandel NS, Schumacker PT, Thorp EB
  Title
Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair.
  Journal
Cell Metab 29:443-456.e5 (2019)
DOI:10.1016/j.cmet.2018.12.004
Reference
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
  Authors
Trzeciak A, Wang YT, Perry JSA
  Title
First we eat, then we do everything else: The dynamic metabolic regulation of efferocytosis.
  Journal
Cell Metab 33:2126-2141 (2021)
DOI:10.1016/j.cmet.2021.08.001
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