KEGG   NETWORK: N01780
Entry
N01780                      Network                                
Name
Hydrolyzing AC-derived cholesterol esters in the lysosome
Definition
CE -- LIPA -> Cholesterol+FA
  Expanded
C02530 -- 3988 -> C00187+C00162
Class
nt06535 Efferocytosis
Type
Reference
Pathway
hsa04148 Efferocytosis   
Gene
3988  LIPA; lipase A, lysosomal acid type
Metabolite
C02530  Cholesterol ester
C00187  Cholesterol
C00162  Fatty acid
Reference
  Authors
Gomaraschi M, Bonacina F, Norata GD
  Title
Lysosomal Acid Lipase: From Cellular Lipid Handler to Immunometabolic Target.
  Journal
Trends Pharmacol Sci 40:104-115 (2019)
DOI:10.1016/j.tips.2018.12.006
Reference
  Authors
Viaud M, Ivanov S, Vujic N, Duta-Mare M, Aira LE, Barouillet T, Garcia E, Orange F, Dugail I, Hainault I, Stehlik C, Marchetti S, Boyer L, Guinamard R, Foufelle F, Bochem A, Hovingh KG, Thorp EB, Gautier EL, Kratky D, Dasilva-Jardine P, Yvan-Charvet L
  Title
Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol Production.
  Journal
Circ Res 122:1369-1384 (2018)
DOI:10.1161/CIRCRESAHA.117.312333
Reference
  Authors
Mota AC, Dominguez M, Weigert A, Snodgrass RG, Namgaladze D, Brune B
  Title
Lysosome-Dependent LXR and PPARdelta Activation Upon Efferocytosis in Human Macrophages.
  Journal
Front Immunol 12:637778 (2021)
DOI:10.3389/fimmu.2021.637778
Reference
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
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