KEGG   NETWORK: N01818
Entry
N01818                      Network                                
Name
Actin thin filament, muscle contraction
Definition
Ca2+ -> (TNNC+TNNI+TNNT) -| TPM -| ACTA/C == MYH == Myosin_thick_filament
  Expanded
C00076 -> ((7134+7135+7138),(7125+7136+7140),(7134+7137+7139)) -| (7168,7169,7170) -| (58,70) == (4619,4620,4621,4622,4624,4625,57644,4626,4629,8735,22989) == Myosin_thick_filament
Class
nt06539 Cytoskeleton in muscle cells
Type
Reference
Pathway
hsa04820  Cytoskeleton in muscle cells
Gene
7134  TNNC1; troponin C1, slow skeletal and cardiac type
7125  TNNC2; troponin C2, fast skeletal type
7135  TNNI1; troponin I1, slow skeletal type
7136  TNNI2; troponin I2, fast skeletal type
7137  TNNI3; troponin I3, cardiac type
7138  TNNT1; troponin T1, slow skeletal type
7139  TNNT2; troponin T2, cardiac type
7140  TNNT3; troponin T3, fast skeletal type
7168  TPM1; tropomyosin 1
7169  TPM2; tropomyosin 2
7170  TPM3; tropomyosin 3
58  ACTA1; actin alpha 1, skeletal muscle
70  ACTC1; actin alpha cardiac muscle 1
4619  MYH1; myosin heavy chain 1
4620  MYH2; myosin heavy chain 2
4621  MYH3; myosin heavy chain 3
4622  MYH4; myosin heavy chain 4
4624  MYH6; myosin heavy chain 6
4625  MYH7; myosin heavy chain 7
57644  MYH7B; myosin heavy chain 7B
4626  MYH8; myosin heavy chain 8
4629  MYH11; myosin heavy chain 11
8735  MYH13; myosin heavy chain 13
22989  MYH15; myosin heavy chain 15
Metabolite
C00076  Calcium cation
Reference
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
  Authors
Smith LR, Meyer G, Lieber RL
  Title
Systems analysis of biological networks in skeletal muscle function.
  Journal
Wiley Interdiscip Rev Syst Biol Med 5:55-71 (2013)
DOI:10.1002/wsbm.1197
LinkDB

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