KEGG   DISEASE: Tick-borne lymphadenopathy
Entry
H01397                      Disease                                
Name
Tick-borne lymphadenopathy;
Tick-borne lymphadenitis
Description
Rickettsia species are arthropod-associated intracellular bacteria and cause diseases in human such as Tick-borne lymphadenopathy, Typhus fever and Spotted fever. Rickettsia slovaca has been isolated from Dermacentor ticks and is the main agent of tick-borne lymphadenopathy (TIBOLA), which is found only in Europe. Its symptoms are generally mild and can be characterized by inoculation eschar on the scalp and cervical lymphadenopathies after a tick bite. Moreover, most of the cases occur during European cool months related to the activity of Dermacentor ticks.
Category
Bacterial infectious disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
 11 Diseases of the circulatory system
  Disorders of lymphatic vessels or lymph nodes
   BD90  Lymphadenitis
    H01397  Tick-borne lymphadenopathy
Genome-based classification of infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by alpha proteobacteria
   H01397  Tick-borne lymphadenopathy
Pathogen
Rickettsia slovaca [GN:rsv]
Comment
Intermediate host: Dermacentor marginatus and Dermacentor reticulatus
Other DBs
ICD-11: BD90.Y
ICD-10: R59 L04 I88
MeSH: D008199 D008206
Reference
  Authors
Fournier PE, El Karkouri K, Robert C, Medigue C, Raoult D
  Title
Complete genome sequence of Rickettsia slovaca, the agent of tick-borne lymphadenitis.
  Journal
J Bacteriol 194:1612 (2012)
DOI:10.1128/JB.06625-11
Reference
  Authors
Dobler G, Wolfel R
  Title
Typhus and other rickettsioses: emerging infections in Germany.
  Journal
Dtsch Arztebl Int 106:348-54 (2009)
DOI:10.3238/arztebl.2009.0348
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