Human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) are human pathogens of members of beta-herpesvirus. Primary infection with HHV-6 and HHV-7 occurs in early childhood and causes short febrile diseases, sometimes associated with cutaneous rash (exanthem subitum). HHV-6 and HHV-7 establish latency in the host following primary infection and may reactivate.