KEGG   VARIANT: 1565v1
Entry
1565v1                      Variant                                
Name
CYP2D6 polymorphism for poor drug metabolism
Gene
CYP2D6  cytochrome P450 family 2 subfamily D member 6 [KO:K17712]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
*3
dbSNP: rs35742686
Variation
*4 G>A at splice site
ClinVar: 16889
dbSNP: rs3892097
Variation
*5 deletion
ClinVar: 16890
Variation
*6
dbSNP: rs5030655
Reference
  Authors
Zanger UM, Raimundo S, Eichelbaum M
  Title
Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 369:23-37 (2004)
DOI:10.1007/s00210-003-0832-2
Reference
  Authors
Hicks JK, Bishop JR, Sangkuhl K, Muller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A
  Title
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors.
  Journal
Clin Pharmacol Ther 98:127-34 (2015)
DOI:10.1002/cpt.147
Reference
  Authors
Zhou SF
  Title
Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I.
  Journal
Clin Pharmacokinet 48:689-723 (2009)
DOI:10.2165/11318030-000000000-00000
Reference
  Authors
Gardiner SJ, Begg EJ
  Title
Pharmacogenetics, drug-metabolizing enzymes, and clinical practice.
  Journal
Pharmacol Rev 58:521-90 (2006)
DOI:10.1124/pr.58.3.6
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