KEGG   VARIANT: 4233v3
Entry
4233v3                      Variant                                
Name
MET amplification
Gene
MET  MET proto-oncogene, receptor tyrosine kinase [KO:K05099]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
amplification
ClinVar: 59715
dbVar: nsv532243
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06261  Gastric cancer
nt06526  MAPK signaling
nt06530  PI3K signaling
Disease
H00018  Gastric cancer
Reference
  Authors
Kawakami H, Okamoto I, Okamoto W, Tanizaki J, Nakagawa K, Nishio K
  Title
Targeting MET Amplification as a New Oncogenic Driver.
  Journal
Cancers (Basel) 6:1540-52 (2014)
DOI:10.3390/cancers6031540
Reference
  Authors
Riquelme I, Saavedra K, Espinoza JA, Weber H, Garcia P, Nervi B, Garrido M, Corvalan AH, Roa JC, Bizama C
  Title
Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy.
  Journal
Oncotarget 6:24750-79 (2015)
DOI:10.18632/oncotarget.4990
Reference
  Authors
Panani AD
  Title
Cytogenetic and molecular aspects of gastric cancer: clinical implications.
  Journal
Cancer Lett 266:99-115 (2008)
DOI:10.1016/j.canlet.2008.02.053
Reference
  Authors
Vauhkonen M, Vauhkonen H, Sipponen P
  Title
Pathology and molecular biology of gastric cancer.
  Journal
Best Pract Res Clin Gastroenterol 20:651-74 (2006)
DOI:10.1016/j.bpg.2006.03.016
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