| Date | ko/br no | Title | Status |
| 2024-2-1 | 04052 | Cytokines and neuropeptides | Title changed |
| 2024-1-9 | 08623 | Viruses in pathway maps | Newly added table file |
| 2023-9-12 | 08622 | KEGG selected viruses | Newly added table file; converted from virus list |
| 2023-9-1 | 08308 | Narcotics and psychotropics | Newly added table file |
| 2023-8-19 | 08406 | Infectious diseases by law in Japan | English version added |
| 2023-8-19 | 08416 | Specified pathogens by law in Japan | English version added |
| 2023-7-7 | 08110 | Blood groups and carbohydrate antigens | Newly added table file |
| 2023-4-24 | 08402 | Pathway-based classification of diseases | Title changed; Data reorganized |
| 2023-4-24 | 08401 | Genome-based classification of infectious diseases | Title changed |
| 2023-4-4 | 08120 | O-antigens | Newly added; changed from table file |
| 2023-3-7 | 03223 | Viral network perturbations | Newly added table file |
| 2023-3-3 | 08431 | Carbohydrates in viral and bacterial infections | Deleted; trabsferred to 03220 |
| 2022-12-28 | 08012 | Dietary phytochemicals | Newly added table file |
| 2022-10-11 | 08011 | Secondary metabolites in pathway maps | Newly added table file |
| 2022-7-15 | 08120 | O-antigen repeat unit structures | Newly added table file |
| 2022-7-11 | 08611 | KEGG organisms in taxonomic ranks | Title changed |
| 2022-7-11 | 08621 | KEGG viruses in taxonomic ranks | Title changed |
| 2022-6-22 | 03220 | Virus entry | Title changed |
| 2022-6-22 | 03222 | Virus entry: animal viruses | Newly added table file |
| 2022-5-30 | 08612 | KEGG organisms: animals | Newly added |
| 2022-5-30 | 08613 | KEGG organisms: plants | Newly added |
| 2022-5-30 | 08614 | KEGG organisms: fungi | Newly added |
| 2022-5-30 | 08615 | KEGG organisms: protists | Newly added |
| 2022-5-30 | 08602 | Animal classification | Deleted |
| 2022-5-30 | 08603 | Plant classification | Deleted |
| 2022-4-5 | 03037 | Cilium and associated proteins | Newly added |
| 2022-3-7 | 03220 | Enveloped virus entry | Newly added table file |
| 2021-12-9 | 08330 | Drug groups | Newly added |
| 2021-12-9 | 08332 | Drug classes | Newly added |
| 2021-11-1 | 08010 | Target-based classification of compounds | Deleted |
| 2021-11-1 | 08501 | Human organ systems | Deleted |
| 2021-11-1 | 08502 | Human cells | Deleted |
| 2021-10-13 | 08020 | Nucleotide sugars | Newly added table file |
| 2021-6-10 | 08327 | Antimicrobials abbreviations | Newly added |
| 2021-6-10 | 08307 | Antimicrobials | Title changed |
| 2021-6-1 | 08621 | KEGG viruses | Newly added; computationally generated |
| 2021-4-13 | 08008 | Carcinogens | Deleted |
| 2021-4-9 | 08321 | Essential oils | Deleted |
| 2021-4-9 | 08322 | Medicinal herbs | Deleted |
| 2021-4-9 | 08323 | Major components of natural products | Deleted |
| 2021-3-29 | 08307 | Antiinfectives | Reinstated |
| 2021-1-14 | 08316 | Pharmaceutical additives in Japan | English version deleted; Japanese version only |
| 2020-12-8 | 03210 | Viral fusion proteins | Newly added |
| 2020-10-19 | 04990 | Domain-containing proteins not elsewhere classified | Newly added |
| 2020-10-16 | 08607 | Endosymbionts | Deleted |
| 2020-4-1 | 08309 | Drug metabolizing enzymes and transporters | Reinstated with a different title |
| 2019-10-11 | 08021 | Glycosides | Newly added |
| 2019-5-30 | 01613 | Aminoacyl-tRNA synthetases | Newly added table file |
| 2019-4-26 | 08416 | Specified pathogens by law in Japan (in Japanese) | Newly added table file |
| 2018-8-1 | 08403 | Human diseases in ICD-11 classification | Title changed |
| 2018-5-21 | 04054 | Pattern recognition receptors | Newly added |
| 2018-5-10 | 00000 | KEGG Orthology (KO) - all categories | Number deleted; changed to ko00001_all |
| 2018-5-10 | 04515 | Cell adhesion molecules | Reinstated |
| 2018-5-10 | 04516 | Cell adhesion molecules and their ligands | Deleted |
| 2018-5-2 | 08310 | Target-based classification of drugs | Major update; Japanese version deleted |
| 2018-4-13 | 01020 | Enzyme-linked receptors | Deleted; merged into 01001 |
| 2018-3-29 | 08324 | Prodrugs | Newly added table file |
| 2018-3-29 | 08350 | Antiinfectives | Reinstated combining 08350-08353; title changed |
| 2018-3-29 | 08307 | Antiinfectives | Deleted |
| 2018-2-26 | 08604 | Photosynthetic organisms | Deleted |
| 2018-2-9 | 08309 | Cytochrome P450 interactions | Deleted |
| 2018-2-7 | 08317 | Topical steroids potency | Reinstated |
| 2018-2-7 | 08360 | Drug classes of therapeutic agents | New brite table number combining 08361-08373 |
| 2018-2-7 | 08350 | Antibacterials | Deleted |
| 2018-2-7 | 08351 | Antivirals | Deleted |
| 2018-2-7 | 08352 | Antifungals | Deleted |
| 2018-2-7 | 08353 | Antiparasitics | Deleted |
| 2018-2-7 | 08361 | Antidiabetics | Deleted |
| 2018-2-7 | 08365 | Hypolipidemic agents | Deleted |
| 2018-2-7 | 08368 | Osteoporosis drugs | Deleted |
| 2018-2-7 | 08364 | Cardiovascular agents | Deleted |
| 2018-2-7 | 08363 | Psychiatric agents | Deleted |
| 2018-2-7 | 08367 | Neurological agents | Deleted |
| 2018-2-7 | 08362 | Anti-allergic agents | Deleted |
| 2018-2-7 | 08366 | Antirheumatic and antigout drugs | Deleted |
| 2018-2-7 | 08369 | Anesthetics, analgesics and anti-inflammatory drugs | Deleted |
| 2018-2-7 | 08372 | Respiratory agents | Deleted |
| 2018-2-7 | 08371 | Gastrointestinal agents | Deleted |
| 2018-2-7 | 08373 | Endocrine and hormonal agents | Deleted |
| 2018-2-7 | 08370 | Dermatological agents | Deleted |
| 2018-2-5 | 08355 | Orphan drugs in the USA | Deleted |
| 2018-2-5 | 08354 | Orphan drugs in Japan | Deleted |
| 2018-2-5 | 08306 | Phytochemicals used as drugs | Deleted |
| 2017-12-30 | 01612 | DNA polymerases | Newly added table file |
| 2017-11-28 | 08907 | KEGG networks | Newly added |
| 2017-11-27 | 05201 | Cancer stages | Deleted |
| 2017-11-7 | 01600 | Antimicrobial resistance: KEGG signatures | New brite table number; changed from 08451 |
| 2017-11-7 | 08452 | Antimicrobial resistance: KEGG organisms | Deleted |
| 2017-11-7 | 01553 | Antimicrobial resistance: beta-lactamase genes | New brite table number; changed from 08453 |
| 2017-11-7 | 01554 | Antimicrobial resistance: aminoglycoside resistance genes | New brite table number; changed from 08454 |
| 2017-11-7 | 01556 | Antimicrobial resistance: tetracyclin resistance genes | New brite table number; changed from 08456 |
| 2017-11-7 | 01555 | Antimicrobial resistance: macrolide resistance genes | New brite table number; changed from 08455 |
| 2017-11-7 | 01557 | Antimicrobial resistance: others | New brite table number; changed from 08457 |
| 2017-9-21 | 01601 | Enzymes of 2-oxocarboxylic acid metabolism | New brite table number; changed from 06001 |
| 2017-9-21 | 01602 | Dioxygenases | New brite table number; changed from 06002 |
| 2017-9-21 | 01610 | Ribosomal proteins | New brite table number; changed from 06010 |
| 2017-9-21 | 01611 | RNA polymerases | New brite table number; changed from 06011 |
| 2017-9-21 | 01620 | Photosynthetic and chemosynthetic capacities | New brite table number; changed from 06020 |
| 2017-9-21 | 01621 | Signaling Modules | New brite table number; changed from 06021 |
| 2017-9-21 | 01800 | Sequence Data for EC Numbers | New brite table number; changed from 06100 |
| 2017-9-21 | 01810 | Sequence Data for CYP Nomenclature | New brite table number; changed from 06110 |
| 2017-8-1 | 00000 | KEGG Orthology (KO) - all categories | Newly added |
| 2017-6-15 | 06110 | Sequence data for CYP nomenclature | Title changed |
| 2017-4-3 | 01011 | Peptidoglycan biosynthesis and degradation proteins | Newly added |
| 2017-1-5 | 08457 | Antimicrobial resistance: others | Newly added table file |
| 2017-1-1 | 06110 | Cytochrome P450 | Newly added table file |
| 2016-12-5 | 08329 | New drug approvals in Europe | Newly added table file |
| 2016-12-5 | 08328 | New drug approvals in the USA, Europe and Japan | Newly added table file |
| 2016-11-15 | 08370 | Dermatological agents | Newly added table file |
| 2016-11-15 | 08317 | Topical steroids | Replaced by 08370 |
| 2016-9-1 | 04131 | Membrane trafficking | Title changed |
| 2016-7-1 | 08620 | KEGG viruses in the NCBI taxonomy | Newly added |
| 2016-3-30 | 08355 | Orphan drugs in the USA | Newly added table file |
| 2016-3-30 | 08354 | Orphan drugs in Japan (Japanese only) | Newly added table file |
| 2016-3-22 | 08371 | Gastrointestinal agents | Newly added table file |
| 2016-3-8 | 00537 | Glycosylphosphatidylinositol (GPI)-anchored proteins | Newly added |
| 2016-3-4 | 01504 | Antimicrobial resistance genes | Newly added |
| 2016-1-15 | 08307 | Antiinfectives | Changed back from table to htext file |
| 2015-10-20 | 08372 | Respiratory agents | Newly added table file |
| 2015-10-16 | 08373 | Endocrine and hormonal agents | Newly added table file |
| 2015-10-12 | 08350 | Antibacterials | Newly added table file |
| 2015-10-9 | 08353 | Antiparasitics | Newly added table file |
| 2015-10-1 | 08454 | Antimicrobial resistance: aminoglycoside resistance genes | Newly added table file |
| 2015-10-1 | 08456 | Antimicrobial resistance: tetracycline resistance genes | Newly added table file |
| 2015-10-1 | 08455 | Antimicrobial resistance: macrolide resistance genes | Newly added table file |
| 2015-9-16 | 08366 | Antirheumatic and antigout drugs | Newly added table file |
| 2015-8-6 | 08367 | Neurological agents | Newly added table file |
| 2015-7-23 | 08369 | Anesthetics and analgesics | Newly added table file |
| 2015-6-19 | 08368 | Osteoporosis drugs | Newly added table file |
| 2015-6-11 | 08364 | Cardiovascular agents | Newly added table file |
| 2015-6-10 | 08365 | Hypolipidemic agents | Newly added table file |
| 2015-6-9 | 08351 | Antivirals | Newly added table file |
| 2015-6-9 | 08352 | Antifungals | Newly added table file |
| 2015-6-8 | 08431 | Carbohydrates in viral and bacterial infections | Newly added table file |
| 2015-5-1 | 02048 | Prokaryotic defense system | Newly added |
| 2015-4-28 | 08412 | Specified intractable diseases in Japan (Japanese only) | Newly added table file |
| 2015-4-22 | 06001 | Enzymes of 2-oxocarboxylic acid metabolism | Included in BRITE as table file |
| 2015-4-22 | 06002 | Dioxygenases | Included in BRITE as table file |
| 2015-4-22 | 06010 | Ribosomal proteins | Included in BRITE as table file |
| 2015-4-22 | 06011 | RNA polymerases | Included in BRITE as table file |
| 2015-4-22 | 06020 | Photosynthetic and chemosynthetic capacities | Included in BRITE as table file |
| 2015-4-22 | 06021 | Signaling modules | Included in BRITE as table file |
| 2015-4-21 | 08363 | Psychiatric agents | Newly added table file |
| 2015-4-21 | 08362 | Anti-allergic agents | Newly added table file |
| 2015-4-1 | 08451 | Antibiotic resistance: KEGG signatures | Newly added table file |
| 2015-4-1 | 08452 | Antibiotic resistance: KEGG organisms | Newly added table file |
| 2015-4-1 | 08453 | Antibiotic resistance: beta-Lactamases | Newly added table file |
| 2015-3-30 | 08361 | Antidiabetics | Newly added table file |
| 2015-3-26 | 08340 | Antineoplastics | New brite table number; changed from 08308 |
| 2015-3-9 | 08307 | Antiinfectives | Converted from htext to table file |
| 2015-3-6 | 00536 | Glycosaminoglycan binding proteins | Title changed |
| 2015-3-5 | 08308 | Antineoplastics | Converted from htext to table file |
| 2015-3-2 | 08317 | Topical steroids | Converted from htext to table file; Title changed |
| 2015-3-2 | 08406 | Infectious diseases by law in Japan (Japanese only) | Converted from htext to table file |
| 2015-2-16 | 08319 | New Drug Approvals in the U.S.A. | Newly added table file |
| 2015-2-16 | 08318 | New Drug Approvals in Japan (Japanese only) | Newly added table file |
| 2014-12-8 | 03019 | Messenger RNA biogenesis | Newly added |
| 2014-11-12 | 08442 | Tumor markers | Newly added table file |
| 2014-9-12 | 08441 | Cancer-accociated carbohydrates | Newly added table file |
| 2014-7-9 | 08323 | Major components of natural products | Computationally generated from 08305, 08321, 08322 |
| 2014-5-30 | 08611 | KEGG prokaryotes in the NCBI taxonomy | Computationally generated from 08601 |
| 2014-5-29 | 08610 | KEGG organisms in the NCBI taxonomy | Computationally generated from 08601 |
| 2014-3-6 | 01009 | Protein phosphatases and associated proteins | Newly added |
| 2014-2-12 | 03029 | Mitochondrial biogenesis | Newly added |
| 2013-11-26 | 08309 | Cytochrome P450 interactions | Newly added |
| 2013-9-27 | 08010 | Target-based classification of compounds | Newly added |
| 2013-9-27 | 04091 | Lectins | Title changed |
| 2013-7-26 | 08317 | Topical steroids potency in Japan | Newly added |
| 2013-7-22 | 04147 | Exosome | Newly added |
| 2013-6-14 | 08605 | Plant pathogens | Newly added |
| 2013-6-14 | 03100 | Non-coding RNAs | Newly added |
| 2013-4-22 | 08316 | Pharmaceutical additives | Newly added |
| 2013-3-15 | 00536 | Heparan sulfate/heparin binding proteins | Newly added |
| 2013-3-11 | 02001 | Solute carrier family | Deleted; merged into 02000 |
| 2013-3-5 | 04090 | CD molecules | Title changed |
| 2013-1-30 | 08341 | Genomic biomarkers | Converted from htext to table file |
| 2013-1-10 | 04516 | Cell adhesion molecules and their ligands | Title changed |
| 2013-1-10 | 04515 | Cell adhesion molecules (CAMs) | Deleted; merged into 04516 |
| 2012-10-1 | 00003 | KEGG reaction modules | Newly added |
| 2012-9-14 | 08341 | Genomic biomarkers | Newly added |
| 2012-3-14 | 08009 | Natural toxins | Newly added |
| 2011-12-5 | 01008 | Polyketide biosynthesis proteins | Newly added |
| 2011-9-12 | 03016 | Transfer RNA biogenesis | Newly added |
| 2011-8-22 | 02001 | Solute carrier family | Newly added |
| 2011-7-19 | 08401 | Infectious diseases | Extracted from 08402 |
| 2011-7-19 | 08402 | Diseases with known genetic factors | Title changed; split into two files |
| 2011-6-27 | 03021 | Transcription machinery | Newly added |
| 2011-5-30 | 08310 | Target-based classification of drugs | Newly added |
| 2011-5-24 | 08008 | Carcinogens | Newly added |
| 2011-5-2 | 03009 | Ribosome biogenesis | Newly added |
| 2011-4-4 | 08007 | Pesticides | Newly added |
| 2011-2-3 | 08331 | Animal drugs in Japan | Newly added |
| 2010-12-28 | 08322 | Medicinal herbs | Newly added |
| 2010-12-28 | 01007 | Amino acid related enzymes | Newly added |
| 2010-11-17 | 08006 | Endocrine disrupting compounds | Newly added; split from 08001 |
| 2010-11-17 | 08004 | Polyketides and nonribosomal peptides | Deleted |
| 2010-11-16 | 08308 | Antineoplastics | Newly added |
| 2010-10-25 | 01006 | Prenyltransferases | Newly added |
| 2010-8-30 | 04030 | G protein-coupled receptors | Extracted from 04000 |
| 2010-8-30 | 01020 | Enzyme-linked receptors | Extracted from 04000 |
| 2010-8-30 | 04040 | Cytokine receptors | Extracted from 04000 |
| 2010-8-30 | 03310 | Nuclear receptors | Extracted from 04000 |
| 2010-8-30 | 04040 | Ion channels | Extracted from 04000 |
| 2010-8-30 | 04000 | Receptors and channels | Deleted; split into five files |
| 2010-8-26 | 08101 | Enzyme ligands | Deleted |
| 2010-8-26 | 08102 | Transporter substrates | Deleted |
| 2010-8-26 | 08103 | Ion channel ligands | Deleted |
| 2010-8-26 | 08104 | GPCR ligands | Deleted |
| 2010-8-26 | 08105 | Cytochrome P450 substrates | Deleted |
| 2010-8-26 | 08106 | Nuclear receptor ligands | Deleted |
| 2010-8-22 | 08604 | Photosynthetic organisms | Title changed |
| 2010-8-5 | 08502 | Human cells | Newly added |
| 2010-8-5 | 08501 | Human organ systems | Newly added |
| 2010-7-29 | 08204 | Reaction class | Newly added; computationally generated |
| 2010-7-6 | 08321 | Essential oils | Newly added |
| 2010-4-14 | 03051 | Proteasome | Newly added |
| 2010-1-15 | 03041 | Spliceosome | Newly added |
| 2009-12-29 | 08401 | Pathogens and infectious diseases | Deleted |
| 2009-12-7 | 01005 | Lipopolysaccharide biosynthesis proteins | Newly added |
| 2009-10-13 | 02044 | Secretion system | Newly added |
| 2009-8-12 | 01004 | Lipid biosynthesis proteins | Newly added |
| 2009-5-26 | 08307 | Antiinfectives | Newly added |
| 2009-4-24 | 08604 | Photosynthetic bacteria | Newly added |
| 2009-3-9 | 03036 | Chromosome | Newly added |
| 2009-1-1 | 08306 | Phytochemicals used as drugs | Newly added |
| 2008-8-29 | 02042 | Bacterial toxins | Newly added |
| 2008-7-23 | 03400 | DNA repair and recombination proteins | Newly added |
| 2008-5-16 | 08304 | Traditional Chinese Medicine in Japan | Newly added |
| 2008-3-25 | 08403 | ICD-10 disease classification | Newly added |
| 2008-3-18 | 03032 | DNA replication proteins | Newly added |
| 2008-1-8 | 04121 | Ubiquitin system | Newly added |
| 2007-11-13 | 08302 | USP drug classification | Newly added |
| 2007-10-22 | 04812 | Cytoskeleton proteins | Newly added |
| 2007-9-21 | 08303 | Anatomical Therapeutic Chemical (ATC) classification | Newly added |
| 2007-7-23 | 04091 | Glycan binding proteins | Newly added |
| 2007-6-4 | 08005 | Bioactive peptides | Newly added |
| 2007-4-5 | 08004 | Polyketides and nonribosomal peptides | Newly added |
| 2007-3-14 | 01003 | Glycosyltransferases | Newly added |
| 2007-3-12 | 03110 | Chaperones and folding catalysts | Newly added |
| 2006-12-28 | 03000 | Transcription factors | Newly added |
| 2006-11-10 | 08102 | Transporter substrates | Newly added |
| 2006-10-2 | 01001 | Protein kinases | Newly added |
| 2006-10-1 | 08202 | IUBMB reaction hierarchy | Newly added; computationally generated |
| 2006-10-1 | 08201 | Enzymatic reactions | Newly added; computationally generated |
| 2006-9-30 | 08203 | Glycosyltransferase reactions | Newly added |
| 2006-9-29 | 01002 | Peptidases | Newly added |
| 2006-9-29 | 08106 | Nuclear receptor ligands | Newly added |
| 2006-9-28 | 00194 | Photosynthesis proteins | Newly added |
| 2006-9-5 | 08101 | Enzyme ligands | Newly added; computationally generated |
| 2006-8-21 | 08402 | Human diseases | Newly added |
| 2006-7-19 | 08104 | GPCR ligands | Newly added |
| 2006-7-11 | 04131 | SNAREs | Newly added |
| 2006-5-1 | 04000 | Receptors and channels | Newly added |
| 2006-5-1 | 02000 | Transporters | Newly added |