KEGG ENZYME: 1.1.1.214

ENZYME: 1.1.1.214

Entry

EC 1.1.1.214                Enzyme

Name

2-dehydropantolactone reductase (Si-specific);
2-oxopantoyl lactone reductase;
2-ketopantoyl lactone reductase;
ketopantoyl lactone reductase;
2-dehydropantoyl-lactone reductase (B-specific);
(R)-pantolactone:NADP+ oxidoreductase (B-specific);
2-dehydropantolactone reductase (B-specific)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

(R)-pantolactone:NADP+ oxidoreductase (Si-specific)

Reaction(IUBMB)

(R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+ [RN:R03155]

Reaction(KEGG)

R03155

Substrate

(R)-pantolactone [CPD:C01012];
NADP+ [CPD:C00006]

Product

2-dehydropantolactone [CPD:C01125];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The Escherichia coli enzyme differs from that from yeast [EC 1.1.1.168 2-dehydropantolactone reductase (Re-specific)], which is specific for the Re-face of NADP+, and in receptor requirements from EC 1.1.99.26 3-hydroxycyclohexanone dehydrogenase.

History

EC 1.1.1.214 created 1986, modified 1999, modified 2013

Reference

1 [PMID:234966]

Authors

Wilken DR, King HL Jr, Dyar RE.

Title

Ketopantoic acid and ketopantoyl lactone reductases. Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate.

Journal

J Biol Chem 250:2311-4 (1975)

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.214

IUBMB Enzyme Nomenclature:

1.1.1.214

ExPASy - ENZYME nomenclature database:

1.1.1.214

BRENDA, the Enzyme Database:

1.1.1.214

CAS:	37211-75-9

LinkDB

DBGET integrated database retrieval system