KEGG ENZYME: 2.2.1.8

ENZYME: 2.2.1.8

Entry

EC 2.2.1.8                  Enzyme

Name

fluorothreonine transaldolase

Class

Transferases;
Transferring aldehyde or ketonic groups;
Transketolases and transaldolases

Sysname

fluoroacetaldehyde:L-threonine aldehydetransferase

Reaction(IUBMB)

L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine [RN:R07247]

Reaction(KEGG)

R07247

Substrate

L-threonine [CPD:C00188];
fluoroacetaldehyde [CPD:C15488]

Product

acetaldehyde [CPD:C00084];
4-fluoro-L-threonine [CPD:C15533]

Comment

A pyridoxal phosphate protein. Can also convert chloroacetaldehyde into4-chloro-L-threonine. Unlike EC 2.1.2.1, glycine hydroxymethyltransferase, does not use glycine as a substrate.

History

EC 2.2.1.8 created 2003

Orthology

K18847

fluorothreonine transaldolase

Genes

PZE:	HU754_013160

PHV:	HU739_003080

PGF:	J0G10_17480

NBR:	O3I_021630(glyA)

SDD:	D9753_00470

SCT:	SCAT_p0562(4-FTase)

SCY:	SCATT_p11780

ACTQ:

OG417_43590

ACTN:

L083_1811

Reference

1 [PMID:12404452]

Authors

Murphy CD, O'Hagan D, Schaffrath C.

Title

Identification of a PLP-Dependent Threonine Transaldolase: A Novel Enzyme Involved in 4-Fluorothreonine Biosynthesis in Streptomyces cattleya This work was supported by the Biotechnological and Biological Sciences Research Council and the University of St Andrews.

Journal

Angew Chem Int Ed Engl 40:4479-4481 (2001)
DOI:10.1002/1521-3773(20011203)40:23<4479::AID-ANIE4479>3.0.CO;2-1

Reference

2 [PMID:12738270]

Authors

Murphy CD, Schaffrath C, O'Hagan D.

Title

Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya.

Journal

Chemosphere 52:455-61 (2003)
DOI:10.1016/S0045-6535(03)00191-7

Other DBs

ExplorEnz - The Enzyme Database: