KEGG ENZYME: 2.5.1.53

ENZYME: 2.5.1.53

Entry

EC 2.5.1.53                 Enzyme

Name

uracilylalanine synthase;
O3-acetyl-L-serine acetate-lyase (adding uracil);
isowillardiine synthase;
willardiine synthase;
3-O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase;
O3-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase

Reaction(IUBMB)

O-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate [RN:R03131]

Reaction(KEGG)

R03131

Substrate

O-acetyl-L-serine [CPD:C00979];
uracil [CPD:C00106]

Product

3-(uracil-1-yl)-L-alanine [CPD:C03584];
acetate [CPD:C00033]

Comment

The enzyme produces the non-proteinogenic amino acid L-willardiine, which is naturally found in the plants Acacia willardiana, Mimosa pigra, and Pisum sativum (pea). The enzyme from Pisum species also produces L-isowillardiine. Not identical with EC 2.5.1.47 cysteine synthase.

History

EC 2.5.1.53 created 1990 as EC 4.2.99.16, transferred 2002 to EC 2.5.1.53

Reference

Authors

Ahmmad, M.A.S., Maskall, C.S. and Brown, E.G.

Title

Partial-purification and properties of willardiine and synthase activity from Pisum sativum.

Journal

Phytochemistry 23:265-270 (1984)

Reference

Authors

Ikegami, F., Kaneko, M., Lambein, F., Kuo, Y.-H. and Murakoshi, I.

Title

Difference between uracilylalanine synthases and cysteine synthases in Pisum sativum.

Journal

Phytochemistry 26:2699-2704 (1987)

Reference

Authors

Murakoshi, I., Ikegami, F., Ookawa, N., Ariki, T., Haginiwa, J., Kuo, Y.-H. and Lambein, F.

Title

Biosynthesis of the uracilylalanines willardiine and isowillardiine in higher plants.

Journal

Phytochemistry 17:1571-1576 (1978)

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.53

IUBMB Enzyme Nomenclature:

2.5.1.53

ExPASy - ENZYME nomenclature database:

2.5.1.53

BRENDA, the Enzyme Database:

2.5.1.53

CAS:	113573-73-2

LinkDB

DBGET integrated database retrieval system