KEGG   ENZYME: 4.2.3.34
Entry
EC 4.2.3.34                 Enzyme                                 
Name
stemod-13(17)-ene synthase;
OsKSL11;
stemodene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
9alpha-copalyl-diphosphate diphosphate-lyase [stemod-13(17)-ene-forming]
Reaction(IUBMB)
9alpha-copalyl diphosphate = stemod-13(17)-ene + diphosphate [RN:R09116]
Reaction(KEGG)
R09116
Substrate
9alpha-copalyl diphosphate [CPD:C11902]
Product
stemod-13(17)-ene [CPD:C18224];
diphosphate [CPD:C00013]
Comment
This enzyme catalyses the committed step in the biosynthesis of the stemodane family of diterpenoid secondary metabolites, some of which possess mild antiviral activity. The enzyme also produces stemod-12-ene and stemar-13-ene as minor products.
History
EC 4.2.3.34 created 2008
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K14045  stemod-13(17)-ene synthase
Genes
OGL: 127755082
Reference
1  [PMID:16256063]
  Authors
Morrone D, Jin Y, Xu M, Choi SY, Coates RM, Peters RJ
  Title
An unexpected diterpene cyclase from rice: functional identification of a stemodene synthase.
  Journal
Arch Biochem Biophys 448:133-40 (2006)
DOI:10.1016/j.abb.2005.09.001
  Sequence
[ag:AAZ76733]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.34
IUBMB Enzyme Nomenclature: 4.2.3.34
ExPASy - ENZYME nomenclature database: 4.2.3.34
BRENDA, the Enzyme Database: 4.2.3.34
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