Entry |
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Name |
12beta-hydroxysteroid dehydrogenase;
12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase
|
Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
|
Sysname |
12beta-hydroxysteroid:NADP+ 12-oxidoreductase
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Reaction(IUBMB) |
3alpha,7alpha,12beta-trihydroxy-5beta-cholan-24-oate + NADP+ = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oate + NADPH + H+ [RN: R03495]
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Reaction(KEGG) |
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Substrate |
3alpha,7alpha,12beta-trihydroxy-5beta-cholan-24-oate;
NADP+ [CPD: C00006]
|
Product |
3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oate;
NADPH [CPD: C00005];
H+ [CPD: C00080]
|
Comment |
Acts on a number of bile acids, both in their free and conjugated forms.
|
History |
EC 1.1.1.238 created 1992
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Pathway |
ec00121 | Secondary bile acid biosynthesis |
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Reference |
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Authors |
Edenharder R, Pfutzner A. |
Title |
Characterization of NADP-dependent 12 beta-hydroxysteroid dehydrogenase from Clostridium paraputrificum. |
Journal |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 1.1.1.238 |
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LinkDB |
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