Entry
Name
vellosimine dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
10-deoxysarpagine:NADP+ oxidoreductase
Reaction(IUBMB)
10-deoxysarpagine + NADP+ = vellosimine + NADPH + H+ [RN:
R05827 ]
Reaction(KEGG)
Substrate
Product
Comment
Also acts on related alkaloids with an endo-aldehyde group as vellosimine (same stereochemistry at C-16) but only slight activity with exo-aldehydes. Detected in many cell suspension cultures of plants from the family Apocynaceae.
History
EC 1.1.1.273 created 2002
Pathway
ec00901 Indole alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
Reference
1
Authors
Pfitzner, A., Krausch, B. and Stockigt, J.
Title
Characteristics of vellosimine reductase, a specific enzyme involved in the biosynthesis of the Rauwolfia alkaloid sarpagine.
Journal
Tetrahedron 40:1691-1699 (1984)
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.273
LinkDB
All DBs