Entry |
|
Name |
versiconal hemiacetal acetate reductase;
VHA reductase;
VHA reductase I;
VHA reductase II;
vrdA (gene name)
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Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
|
Sysname |
versiconol-acetate:NADP+ oxidoreductase
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Reaction(IUBMB) |
(1) versicolorone + NADP+ = 1'-hydroxyversicolorone + NADPH + H+ [RN: R09756];
(2) versiconol acetate + NADP+ = versiconal hemiacetal acetate + NADPH + H+ [RN: R10399];
(3) versiconol + NADP+ = versiconal + NADPH + H+ [RN: R10400]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
Isolated from the mold Aspergillus parasiticus. Involved in a metabolic grid that leads to aflatoxin biosynthesis.
|
History |
EC 1.1.1.353 created 2013
|
Pathway |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K17647 | versiconal hemiacetal acetate reductase |
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Genes |
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Reference |
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Authors |
Matsushima K, Ando Y, Hamasaki T, Yabe K |
Title |
Purification and characterization of two versiconal hemiacetal acetate reductases involved in aflatoxin biosynthesis. |
Journal |
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Sequence |
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Reference |
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Authors |
Shima Y, Shiina M, Shinozawa T, Ito Y, Nakajima H, Adachi Y, Yabe K |
Title |
Participation in aflatoxin biosynthesis by a reductase enzyme encoded by vrdA gene outside the aflatoxin gene cluster. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 1.1.1.353 |
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LinkDB |
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