Entry
Name
2'-dehydrokanamycin reductase;
kanK (gene name, ambiguous)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
kanamycin A:NADP+ oxidoreductase
Reaction(IUBMB)
kanamycin A + NADP+ = 2'-dehydrokanamycin A + NADPH + H+ [RN:
R10417 ]
Reaction(KEGG)
Substrate
Product
Comment
Found in the bacterium Streptomyces kanamyceticus where it is involved in the conversion of kanamycin B to kanamycin A.
History
EC 1.1.1.355 created 2013
Pathway
ec00524 Neomycin, kanamycin and gentamicin biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K20152 2'-dehydrokanamycin reductase
Reference
Authors
Sucipto H, Kudo F, Eguchi T
Title
The last step of kanamycin biosynthesis: unique deamination reaction catalyzed by the alpha-ketoglutarate-dependent nonheme iron dioxygenase KanJ and the NADPH-dependent reductase KanK.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.355
LinkDB
All DBs