Entry
Name
dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase;
dTDP-4-dehydro-6-deoxygulose reductase;
tylD (gene name);
gerKI (gene name);
chmD (gene name);
mydI (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
dTDP-6-deoxy-alpha-D-allose:NAD(P)+ oxidoreductase
Reaction(IUBMB)
dTDP-6-deoxy-alpha-D-allose + NAD(P)+ = dTDP-4-dehydro-6-deoxy-alpha-D-gulose + NAD(P)H + H+ [RN:
R06438 R10573 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme forms an activated deoxy-alpha-D-allose, which is converted to mycinose after attachment to the aglycones of several macrolide antibiotics, including tylosin, chalcomycin, dihydrochalcomycin, and mycinamicin II.
History
EC 1.1.1.364 created 2013
Pathway
ec00523 Polyketide sugar unit biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K13313 dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase
Genes
Taxonomy
Reference
Authors
Bate N, Cundliffe E
Title
The mycinose-biosynthetic genes of Streptomyces fradiae, producer of tylosin.
Journal
Sequence
Reference
Authors
Anzai Y, Saito N, Tanaka M, Kinoshita K, Koyama Y, Kato F
Title
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida.
Journal
Sequence
Reference
Authors
Thuy TT, Liou K, Oh TJ, Kim DH, Nam DH, Yoo JC, Sohng JK
Title
Biosynthesis of dTDP-6-deoxy-beta-D-allose, biochemical characterization of dTDP-4-keto-6-deoxyglucose reductase (GerKI) from Streptomyces sp. KCTC 0041BP.
Journal
Sequence
Reference
Authors
Kubiak RL, Phillips RK, Zmudka MW, Ahn MR, Maka EM, Pyeatt GL, Roggensack SJ, Holden HM
Title
Structural and functional studies on a 3'-epimerase involved in the biosynthesis of dTDP-6-deoxy-D-allose.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.364
LinkDB
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