Entry
Name
UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase;
WbjC;
Cap5F
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
UDP-2-acetamido-2,6-dideoxy-L-talose:NADP+ oxidoreductase
Reaction(IUBMB)
UDP-2-acetamido-2,6-dideoxy-beta-L-talose + NAD(P)+ = UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose + NAD(P)H + H+ [RN:
R10665 ]
Reaction(KEGG)
Substrate
UDP-2-acetamido-2,6-dideoxy-beta-L-talose [CPD:
C20768 ];
NAD+ [CPD:
C00003 ];
NADP+ [CPD:
C00006 ]
Product
UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose;
NADH [CPD:
C00004 ];
NADPH [CPD:
C00005 ];
H+ [CPD:
C00080 ]
Comment
Part of the biosynthesis of UDP-N-acetyl-L-fucosamine. Isolated from the bacteria Pseudomonas aeruginosa and Staphylococcus aureus.
History
EC 1.1.1.367 created 2014
Pathway
ec00541 O-Antigen nucleotide sugar biosynthesis
Orthology
K19068 UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase
Genes
ECOO : ECRM13514_2753(fnlB)
ECOH : ECRM13516_2621(fnlB)
CIE : AN232_13735 AN232_31060
PDAG : 4362423_00268(wbjC)
LLZ : LYB30171_02307(wbjC)
PAEB : NCGM1900_3148(wbjC)
SFLA : SPHFLASMR4Y_02428(wbjC)
SSEI : FJR45_01380 FJR45_04470
SAX : USA300HOU_0168(cap5F)
SAA : SAUSA300_0157(cap5F)
SUJ : SAA6159_00138(cap8F)
SUK : SAA6008_00132(cap5F)
SUX : SAEMRSA15_01200(capF)
SUF : SARLGA251_01280(capF)
SAUT : SAI1T1_2001090(cap5F)
SAUJ : SAI2T2_1001090(cap5F)
SAUK : SAI3T3_1001090(cap5F)
SAUQ : SAI4T8_1001090(cap5F)
EAP : KB235_04665 KB235_04855
JAR : G7057_08180 G7057_08365
AACX : DEACI_3856 DEACI_3920 DEACI_3923 DEACI_3975
ACEL : acsn021_22510 acsn021_22560
ACHT : bsdcttw_26930 bsdcttw_26950
CBAR : PATL70BA_0362(wbjC)
TSF : NQ543_04005 NQ543_06840 NQ543_08000
RSA : RSal33209_1612(capF)
VBC : C5Q97_11320 C5Q97_18390
BTHO : Btheta7330_02108 Btheta7330_02998
BFG : BF638R_1089 BF638R_3769
BFE : K6V30_14845 K6V30_24440
PGOL : K6V26_10520 K6V26_11950
RBC : BN938_0769 BN938_1959
CSAL : NBC122_00352(wbjC_1) NBC122_02873(wbjC_2)
» show all
Taxonomy
Reference
Authors
Kneidinger B, O'Riordan K, Li J, Brisson JR, Lee JC, Lam JS
Title
Three highly conserved proteins catalyze the conversion of UDP-N-acetyl-D-glucosamine to precursors for the biosynthesis of O antigen in Pseudomonas aeruginosa O11 and capsule in Staphylococcus aureus type 5. Implications for the UDP-N-acetyl-L-fucosamine biosynthetic pathway.
Journal
Sequence
Reference
Authors
Mulrooney EF, Poon KK, McNally DJ, Brisson JR, Lam JS
Title
Biosynthesis of UDP-N-acetyl-L-fucosamine, a precursor to the biosynthesis of lipopolysaccharide in Pseudomonas aeruginosa serotype O11.
Journal
Reference
Authors
Miyafusa T, Tanaka Y, Kuroda M, Ohta T, Tsumoto K
Title
Expression, purification, crystallization and preliminary diffraction analysis of CapF, a capsular polysaccharide-synthesis enzyme from Staphylococcus aureus.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.367
LinkDB
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