Entry
Name
5-dehydrofumagillol 5-reductase;
af490 (gene name);
Fma-KR
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
fumagillol:NADP+ 5-oxidoreductase
Reaction(IUBMB)
fumagillol + NADP+ = 5-dehydrofumagillol + NADPH + H+ [RN:
R13106 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, characterized from the mold Aspergillus fumigatus, participates in the biosynthesis of the meroterpenoid fumagillin. It is a partial polyketide synthase (PKS) consisting of only a dehydratase (DH) and a ketoreductase (KR) domain.
History
EC 1.1.1.437 created 2022
Pathway
ec00998 Biosynthesis of various antibiotics
ec01110 Biosynthesis of secondary metabolites
Orthology
K22572 5-dehydrofumagillol 5-reductase
Genes
Taxonomy
Reference
Authors
Lin HC, Tsunematsu Y, Dhingra S, Xu W, Fukutomi M, Chooi YH, Cane DE, Calvo AM, Watanabe K, Tang Y
Title
Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.437
LinkDB
All DBs