KEGG ENZYME: 1.1.3.50

ENZYME: 1.1.3.50

Entry

EC 1.1.3.50                 Enzyme

Name

C-glycoside oxidase;
carA (gene name)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor

Sysname

carminate:oxygen 3'-oxidoreductase (H2O2-forming)

Reaction(IUBMB)

carminate + O2 = 3'-dehydrocarminate + H2O2 [RN:R13033]

Reaction(KEGG)

R13033

Substrate

carminate [CPD:C11254];
O2 [CPD:C00007]

Product

3'-dehydrocarminate [CPD:C22530];
H2O2 [CPD:C00027]

Comment

A flavoprotein (FAD). This bacterial enzyme participates in degradation of certain C-glucosides by catalysing the oxidation of the hydroxyl group at position 3 of the glycose moiety. The enzyme was found active with assorted C-glycosides, such as carminate, mangiferin, and C6-glycosylated flavonoids, but not with D-glucose or C8-glycosylated flavonoids.

History

EC 1.1.3.50 created 2022

Orthology

K26081

C-glycoside oxidase

Genes

KPU:

KP1_4211

KPP:

A79E_1147

KVA:

Kvar_1112

PGE:	LG71_16560

EBU:	CUC76_21520

PSV:	PVLB_10685

RHR:	CKA34_30340

RGR:	FZ934_22500

DEQ:	XM25_08810

DEVO:

H4N61_15795

YTI:	FNA67_12540

YPAC:

CEW88_18040

PPAF:

I8N54_00955

MTY:	MTOK_13270

SALB:

XNR_0576

SGRF:

SGFS_021720

SLE:	sle_61010(sle_61010)

SLS:	SLINC_7117

SNR:	SNOUR_10170

SGE:	DWG14_01487(livQ_1)

SAQU:

EJC51_43800

SCHA:

CP983_04300

SCIR:

STRCI_007286

SLON:

LGI35_00400

SCOA:

QU709_05110

MTS:	MTES_1722 MTES_1751

MIX:	AB663_001885

MIH:	BJP65_09690 BJP65_09805

MLV:	CVS47_00305(betA) CVS47_02096 CVS47_02117(livQ)

MBIN:

LXM64_11185

MTEC:

OAU46_01260 OAU46_01375

MRG:	SM116_17740 SM116_17830

MINV:

T9R20_15585 T9R20_15670 T9R20_15740

FSB:	GCM10025867_10980

CPHY:

B5808_02875 B5808_02985

HEH:	L3i23_11070

SUBT:

KPL76_00415

NAEI:

GCM126_00250 GCM126_00270 GCM126_03530 GCM126_03680 GCM126_36360 GCM126_36380

AOG:	LH407_10870

ARR:	ARUE_c17720 ARUE_c17930

ACH:

Achl_3529

APN:	Asphe3_01690 Asphe3_01860

PSNI:

NIBR502771_04420 NIBR502771_04490

GNC:	QQS42_01205 QQS42_01250

TEH:	GKE56_07365 GKE56_07385

NCG:	KGD84_08635

MMAR:

MODMU_2738 MODMU_2760

AMD:

AMED_5392

AMN:

RAM_27490

AMM:

AMES_5327

AMZ:

B737_5327

ATHM:

L1857_14360

KBU:	Q4V64_46695

ACTA:

C1701_00785

DAH:	DAETH_35570

PGIN:

FRZ67_05820

RUP:	DTQ70_10705

RLO:	GQ464_000175

» show all

Reference

1 [PMID:34583991]

Authors

Kumano T, Hori S, Watanabe S, Terashita Y, Yu HY, Hashimoto Y, Senda T, Senda M, Kobayashi M.

Title

FAD-dependent C-glycoside-metabolizing enzymes in microorganisms: Screening, characterization, and crystal structure analysis.

Journal

Proc Natl Acad Sci U S A 118:e2106580118 (2021)
DOI:10.1073/pnas.2106580118

Sequence

[ag:BBE36490]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.3.50

IUBMB Enzyme Nomenclature:

1.1.3.50

ExPASy - ENZYME nomenclature database:

1.1.3.50

BRENDA, the Enzyme Database:

1.1.3.50

LinkDB

DBGET integrated database retrieval system